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Reactivity of chloronitrobenzenes towards glutathione under physiological conditions: The relationship between structure and reaction rate |
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| Authors: | Peter B. Hulbert Nehad M. Hamoodi |
| Affiliation: | Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK |
| Abstract: | An excellent quantitative structure—reactivity correlation between the structural features of CDNB analogues (as expressed by their electronic substituent constants) and the non-enzymic reactivity of these analogues with GSH has been discovered. |
| Keywords: | 1-Chloro-2,4-dinitrobenzene glutathione conjugations structure—activity relationship (QSAR, SAR) Hammett constants Hammett relationship, quantitative chloronitrobenzenes. |
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