子宫内膜异位症在位内膜Bcl-2的表达及其意义

目的 检测子宫内膜异位症在位子宫内膜Ｂｃｌ－２的表达，探讨其在子宫内膜异位症发生机制中的作用。方法 采用免疫组织化学法（ＳＰ法）对４５例盆腔子宫内膜异位症和４４例壁间型子宫肌瘤患者在位子宫内膜进行Ｂｃｌ－２表达检测。结果 （１）对照组Ｂｃｌ－２主要表达于子宫内膜腺上皮细胞胞浆和／或胞膜。增生期Ｂｃｌ－２表达显著高于分泌期（Ｐ〈０．００１）。（２）子宫内膜异位症组Ｂｃｌ－２亦主要表达于子宫内膜腺上皮

A study of Bcl - 2 expression in eutopic endometrium from women with endometriosis

Objective To evaluate the function of Bcl-2 in the etiology or pathogenesis of endometriosis. Methods Immunohistochemistry method (streptavidin-peroxidase method) was used to detect the expression of Bcl-2 protein in eutopic endometrium from patients with endometriosis (45 cases) and intramural myoma of uterus (44 cases). Results 1. The control group: the expression of Bcl-2 predominated in the glandular cytoplasm and /or on the plasma membrane. Bcl-2 expression in proliferative phase was higher than that in secretory phase significantly ( P <0.001). 2. The endometriosis group: Bcl-2 expression also predominated in the glandular cytoplasm and/or on the plasma membrane. Bcl-2 expression in proliferative phase was higher than that in secretory phase ( P <0.05). 3. In endometriosis group that Bcl-2 expression in secretory phase was higher significantly than the control group ( P <0.002). Conclusions The cyclic changes of eutopic endometrium were related to Bcl-2 expression. The patients with endometriosis have a significant enhancement in their anti-apoptotic activity in secretory phase endometrium. It is suggested that the retrograding of these active anti-apoptotic endometrial cells may play a key role in the pathogenesis of endometriosis.