对Ⅱ型糖尿病患者血清载脂蛋白AI与B测定值的评价

采用逐步回归及多变量逐步判别分析,对56例Ⅱ型糖尿病并发动脉粥样硬化、冠心病患者的ApoAI、ApoB、Tch、TG、HDL-C、HDL_2-C、HDL_3-C等血生化指标进行分析。多变量判别结果,DM-A组优选指标男性组是ApoAI/ApoB;女性组是ApoAI/ApoB、TG、HDL_2-C,男、女混合组为ApoAI/ApoB、TG、ApoB、HDL_2-G。三组中优选值都有ApoAI/ApoB,且P值最小,可作为糖尿病并发冠心病、动脉硬化症的一项有意义的预测指标。

THE EVALUATION OF APOLIPOPROTEIN AI AND B DETERMINATION IN TYPE II DIABETES MELLITUS

The significance of serum apolipoprotein (Apo) AI and B measurements in the prediction of diabetes meliitus associated with coronary heart disease or atherosclerosis was evaluated, and compared with the results of serum triglyceride (TG), total cholesterol, high density lipoprotein cholesterol (HDL-C) determination. When compared with the control group, TG, FBG and Apo B increased significantly (P<0.01) and HDL-C, HDL2-C decreased significantly (P<0.01) in the DM group. Both multivariant stepwise discrimination and regression analysis demonstrated the superiority of Apo AI/Apo B in male, Apo AI/Apo B, TG,HDL2-C in female and Apo AI/Apo B,TG, Apo B, HDL2-C in the mixed group including both sexes. However, Apo AI/Apo B ratio was the best index in all the above groups. Hence we considered that it is a significant predictor of CHD or atherosclerosis in DM.