VEGF-C和受体Flt-4mRNA在舌鳞癌中的表达及临床意义

目的　研究舌鳞状细胞癌组织中血管内皮生长因子C(vascularendothelialgrowthfactorC ,VEGF C)及其受体VEGFR 3(flt 4 )的表达情况 ,分析其在淋巴转移中的作用。方法　采用RT PCR法分析 2 2例新鲜标本VEGF C/flt 4mRNA的表达情况 ,并统计分析其与各临床病理特点之间的关系。结果　 2 2例中 1 6例VEGF CmRNA表达阳性 ,其中 1 2例flt 4mRNA阳性 ,VEGF C和flt 4mRNA的表达高度一致 (P <0 .0 1 )。舌鳞癌VEGF C明显高于正常组织和良性病变 ;和肿瘤病理分级、肿瘤颈淋巴结转移显著相关 ,和肿瘤发病年龄、性别以及肿瘤T分期无相关性。结论　VEGF C/flt4在舌癌表达高于正常组织和良性病变 ;与肿瘤的预后密切相关。在肿瘤淋巴转移中起重要作用

CLINICOPATHOLOGICAL SIGNIFICANCE OF VASCULAR ENDOTHELIAL GROWTH FACTR C AND ITS RECEPTOR FLT- 4 IN HUMAN TONGUE SQUAMOUS CELL CARCINOMA

Objective The purpose of this study was to investigate the expression of vascular endothelial growth factor C (VEGF C) and its receptor in human tongue SCC, to elucidate their role in lymph node metastasis and other clinical significance. Methods Twenty two fresh specimens was examined by RT PCR to detected the VEGF C/flt 4mRNA expression. Results VEGF C mRNA was detected in 16 of 22 cases which were higher than that in the normal mucosa tissue; there was statistic relation between VEGF C mRNA and flt 4 mRNA. The expression of VEGF C correlated with the grade of tumor pathological and lymph node metastasis. Conclusion The results overall suggest that VEGF C/flt 4 may play an important role in the lymph node metastasis and it could be a useful biological marker to foresee the cervical lymph node metastasis and prognosis.