不同剂量纳络酮治疗早产儿原发性呼吸暂停疗效观察

目的探讨不同剂量纳络酮治疗早产儿原发性呼吸暂停的临床疗效。方法所有患儿均在首次发生呼吸暂停后予以氨茶碱治疗,用至呼吸暂停终止发作后48h,并随机分为纳洛酮大剂量治疗组和小剂量治疗组。结果与小剂量治疗组比较,大剂量组日平均发生呼吸暂停次数减少(P<0.01),暂停持续时间、消失时间、氨茶碱使用时间缩短(P<0.01),发生呼吸暂停时心率、SpO2下降程度减轻(P<0.01)。大剂量治疗组总有效率95.0%,而小剂量组总有效率为72.5%,大剂量治疗组优于小剂量组(P<0.05)。结论应用较大剂量纳络酮治疗早产儿原发性呼吸暂较小剂量更为有效,值得临床推广使用。

The clinical research of different dosage naloxone in treatment on primary apnea in premature infants

Object To observe the clinical benefits of different dosage Naloxone in treatment on primary apnea.Methods All the infants were treated with minophyalline after first onset of apnea until the condition was absent for 48 hours and were randomly divided into two groups ,one group received big dosage Naloxone with an initial dose of 100 μg /kg, followed by 40 μg·kg-1·h-1intravenous pumping lasting 6～8 hours daily for 5 consecutive days, the other group received small dosage Naloxone with an initial dose of 50 μg/kg, followed by 20 μg·kg-1·h-1intravenous pumping lasting 6～8 hours daily for 5 consecutive days.Results Compared with the small dosage group, the big dosage group experienced less episodes of apnea (P<0.01),shortered duration of apnea and less aminophylline days.Reduction in SpO2 and heart rate were alleviated with the big dosage group.The total effective rates of the big dosage group were 95.0%, much lower than that in the small dosage group(72.5%)( P<0.05).Conclusion The big dosage Naloxone in treatment of primarily apnea of premature infants showed better benefit compared with the small dosage Naloxone ,and is worthy of recommendation for use in primarily apnea of premature infants.