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Endocrine responses to thyrotropin-releasing hormone in major depressive disorders |
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| Authors: | G M Asnis E J Sachar U Halbreich R S Nathan L Ostrow M Soloman F S Halpern |
| Institution: | 1. Gregory M. Asnis, M.D., is Assistant Professor, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA;2. Edward J. Sachar, M.D., is Professor and Chairman, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA;3. Lynn C. Ostrow, R.N., M.A., is Research Nurse, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA;4. Frieda S. Halpern, M.A., is Assistant Professor, Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA;5. Murray Solomon, M.S., is Research Scientist at the New York State Psychiatric Institute, USA;6. Uriel Halbreich, M.D., is Director, Division of Behavioral Endocrinology, Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY, USA;7. R. Swami Nathan, M.D., is Assistant Professor, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA |
| Abstract: | The endocrine response to thyrotropin-releasing hormone (TRH) was studied in severely endogenously depressed patients during illness (n = 21) and after recovery (n = 18). The thyroid-stimulating hormone (TSH) response to TRH was blunted (deltaTSH less than 5 microIU/ml) in over one third of depressives during illness and remained blunted in most even after recovery. There was no correlation between multiple measures of cortisol secretion (the mean 24-hour plasma cortisol, dexamethasone suppression test, and plasma cortisol during the TRH procedure) and the TSH response during illness and after recovery. The TSH and prolactin (PRL) responses to TRH, as well as the baseline PRL, were significantly lower during illness. The role of possible abnormalities in dopamine and/or serotonin in depression contributing to these endocrine disturbances is discussed. |
| Keywords: | Reprint requests to Dr G M Asnis Dept of Psychiatry Columbia University College of Physicians and Surgeons 722 W 168 St New York NY 10032 USA |
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