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Murine Cytomegalovirus (MCMV) Infection Upregulates P38 MAP kinase in Aortas of Apo E KO Mice: a Molecular Mechanism for MCMV-Induced Acceleration of Atherosclerosis |
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| Authors: | Yajarayma J Tang-Feldman Stephanie R Lochhead G Raymond Lochhead Cindy Yu Michael George Amparo C Villablanca Claire Pomeroy |
| Institution: | 1. Department of Internal Medicine, University of California, Davis, Sacramento, CA, 95817, USA 2. Department of Pathology, University of California, Davis, Sacramento, CA, 95817, USA 3. Department of Medical Microbiology and Immunology, University of California, Davis, Sacramento, CA, 95817, USA 4. Department of Internal Medicine and Department of Medical Microbiology and Immunology, University of California, Davis, Sacramento, CA, 95817, USA |
| Abstract: | Multiple studies suggest an association between cytomegalovirus (CMV) infection and atherogenesis; however, the molecular mechanisms by which viral infection might exacerbate atherosclerosis are not well understood. Aortas of MCMV-infected and uninfected Apo E knockout (KO) mice were analyzed for atherosclerotic lesion development and differential gene expression. Lesions in the infected mice were larger and showed more advanced disease compared to the uninfected mice. Sixty percent of the genes in the MAPK pathway were upregulated in the infected mice. p38 and ERK 1/2 MAPK genes were 5.6- and 2.0-fold higher, respectively, in aortas of infected vs. uninfected mice. Levels of VCAM-1, ICAM-1, and MCP-1 were ~2.0–2.6-fold higher in aortas of infected vs. uninfected mice. Inhibition of p38 with SB203580 resulted in lower levels of pro-atherogenic molecules and MCMV viral load in aortas of infected mice. MCMV-induced upregulation of p38 may drive the virus-induced acceleration of atherogenesis observed in our model. |
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