Lack of Correlation Between Clinical Characteristics and Serum Soluble Fas Ligand Levels in Patients with Multiple Myeloma |
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| Authors: | Yoshinobu Kanda Chiaki Arai Akichizuka Rie Yamamoto Tamae Hamaki Miyuki Suguro Tomohiro Matsuyama Naoki Takezako Akiyoshi Miwa Junko Tohma Kamon Shirakawa Takehiro Yatomi Norio Nakamura Hisamaru Hirai Atsushi Togawa |
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| Affiliation: | a Department of Hematology, International Medical Center of Japan, Japanb Biosciences Laboratory, Research Center, Mochida Pharmaceutical Co, Japanc Department of Cell Therapy & Transplantation Medicine, Faculty of Medicine, University of Tokyo, Japan |
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| Abstract: | Multiple myeloma is characterized by the accumulation of malignant plasma cells in the bone marrow and rarely cured by chemotherapy. Villunger et al. showed that the neoplastic plasma cells express Fas ligand (FasL), which transmits a signal of apoptosis upon ligation to Fas, and suggested that the FasL suppresses the T-cells activated against malignant cells, resulting in escape from tumour immunity. We examined serum soluble FasL (sFasL) levels in 35 multiple myeloma patients to evaluate the correlation between sFasL levels and clinical characteristics. The serum sFasL levels were not affected by the disease status, serum monoclonal protein levels, or other prognostic factors. We could not determine whether the expression of FasL is involved in the poor clinical course of the disease. |
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| Keywords: | Fas Fas ligand soluble multiple myeloma |
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