上海市沙门菌血清型流行特征

目的建立本市沙门菌数据库,初步了解本地区部分沙门菌血清型的流行特征。方法以1999-2007年于从业人员体检、食品、腹泻病人质控(QC)和沙门菌监测对象分离的1078株沙门菌的血清型进行回顾性分析;其中2006年和2007年按照全球沙门菌监测(GSS)方案进行连续性腹泻病例监测。结果血清型谱显示本市不同来源的沙门菌型在分布上存在优势交叉,GSS分离菌株中有7个型为国内首次报告;通过分子分型证明本市2006年的山夫登堡和2007年的汤卜逊病例分别属于2个和1个克隆型。结论肠炎、鼠伤寒仍是本市优势致泻性血清型,山夫登堡和汤卜逊病例符合沙门菌性相对散发和集中暴发的分子流行特征。加强对沙门菌综合监测和准确及时的血清、分子分型能力有助于检索和追溯流行菌型。

Epidemiological characteristics of serotypes of Salmonella isolated in Shanghai

The databank for Salmonella in Shanghai was established in order to investigate the epidemiological characteristics of Salmonella isolated in Shanghai, by which the serotypes of 1 078 strains of Salmonella isolated from foods, food handlings, diarrhea patients, samples subjected to quality control （QC） and surveillance for salmonelloisis from 1999 to 2007 were analyzed retrospectively and patients with diarrhea were successively surveyed with the Global Salmonella Surveillance （GSS） method in 2006 to 2007. It was demonstrated that the Salmonella serotype spectrum showed the dominant intersection among serotypes of Salmonella isolated from different sources, in which 7 serotypes of isolates from GSS were confirmed to be firstly reported in China. By molecular typing analysis, it was demonstrated that S. senftenberg isolated in 2006 and S. thompson isolated in 2007 belong to two and one clone types respectively, S. enteriditis and S. typhimurium were the two dominant diarrheic Salmonella found in Shanghai. The epidemiologieal characteristics and molecular typing on S. senftenberg and S. thompson were corresponded with the relatively sporadic and outbreak cases. It is apparent that the comprehensive survey and the real time serotyping and molecular typing may help to search the source of the epidemic strains of Salmonella.