根除幽门螺杆菌感染对慢性胃炎的疗效分析

目的探讨慢性胃炎根除Hp患者临床症状、内镜表现及病理变化,明确根除Hp对慢性胃炎的疗效。方法对内镜诊断为慢性胃炎合并Hp阳性患者100例,分为Hp阳性耐药治疗组60例,Hp阳性耐药对照组40例。均以铝碳酸镁片1.0 g口服,3次/日,8周。8周后检测Hp,复查胃镜后评估消化道症状及胃镜改变。结果两组治疗前后症状总评分、内镜下糜烂改变有统计学意义(P<0.05)。Hp阳性耐药治疗组治疗前后症状评分差值为(3.42±1.25),显著高于Hp阳性耐药对照组(2.80±1.24)(P<0.05)。结论伴有Hp感染的慢性胃炎根除Hp有助于症状改善,在耐药患者Hp根除方案的选择上,序贯疗法的根除率优于四联疗法。

The influence of helicobacter pylori eradication on chronic gastritis

Objective To investigate whether H.pylori eradication has effects on dyspeptic symptoms,erosion and pathology in patients with chronic gastritis infected with H.pylori.Methods One hundred patients with chronic gastritis were randomized into two groups including the treatment group(30 cases underwent a 10 day sequential therapy,30cases received a 7-day quadruple therapy)and the control group(40 cases).All cases receive magnesium sulphate therapy with oral for 8 weeks.Result There was significant difference found in dyspeptic symptoms,erosion,pathology compared with baseline(P <0.05).The decrease in symptom score of the treatment group was(3.33 ± 1.25),significantly higher than that of the control group(2.80 ± 1.24)(P <0.05).Conclusion Patients with chronic gastritis infected with H.pylori should receive eradication therapy early,sequential therapy is associated with better efficacy.