| 抑肽酶对实验性慢性肝损伤大鼠肝细胞增殖能力的影响 |
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| 引用本文： | 王虹蛟,王心童,王强,孟威宏,颜炜群,任立群.抑肽酶对实验性慢性肝损伤大鼠肝细胞增殖能力的影响[J].吉林大学学报(医学版),2011,37(1):18-20. |
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| 作者姓名： | 王虹蛟 王心童 王强 孟威宏 颜炜群 任立群 |
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| 作者单位： | 解放军第461医院内科,吉林,长春130021;吉林大学白求恩医学院临床医学专业2008级;沈阳军区总医院心血管内科,辽宁,沈阳110015;吉林大学再生医学科学研究所,吉林,长春130021 |
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| 摘 要： | 目的:探讨抑肽酶对实验性慢性肝损伤大鼠肝细胞增殖能力的影响,为抑肽酶对慢性肝损伤的保护作用研究提供理论依据.方法:Wistar大鼠随机分为正常对照组、四氯化碳(CCl4)模型组、抑肽酶小剂量组、抑肽酶中剂量组、抑肽酶大剂量组和促肝细胞生长素组,采用免疫组织化学方法检测各组增殖细胞核抗原(PCNA)阳性细胞数和形态学表现...
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| 关 键 词： | 抑肽酶 四氯化碳 慢性肝损伤 大鼠 Wistar 免疫组织化学 细胞增殖 |
| 收稿时间： | 2010-04-14 |
Influence of aprotinin in hepatocyte proliferation ability in rats with experimental chronic liver injury |
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| WANG Hong-jiao,WANG Xin-tong,WANG Qiang,MENG Wei-hong,YAN Wei-qun,REN Li-qun.Influence of aprotinin in hepatocyte proliferation ability in rats with experimental chronic liver injury[J].Journal of Jilin University: Med Ed,2011,37(1):18-20. |
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| Authors: | WANG Hong-jiao WANG Xin-tong WANG Qiang MENG Wei-hong YAN Wei-qun REN Li-qun |
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| Institution: | (1.Department of Internal Medicine,No. 461 Hospital of PLA,Changchun 130021,China;2.Department of Cardiovascular Diseases,General Hospital of Shenyang Military District|Shenyang 110015,China;3. Institute of Frontier Medical Sciences,
Jilin University,Changchun 130021,China) |
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| Abstract: | Objective To study the influence of aprotinin in hepatocyte proliferation ability in rats with experimental chronic liver injury and provide thoreotical basis for study on protective effect of aprotinin on chronic liver injury.Methods Wistar rats were randomly divided into normal control group,carbon tetrachloride(CCl4) model group,low dose aprotinin group,midde dose aprotinin group,high dose aprotinin group and hepatocyte group.Immunohistochemical method was used to observe the proliferating cell nuclear a... |
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| Keywords: | aprotinin carbon tetrachloride chronic hepatic injury rats Wistar immunohistochemistry proliferation |
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