| 促吸收剂癸酸钠对黄连素在大鼠肠道吸收的促进作用 |
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| 引用本文： | 杜函泽,吕晓艳,杜红伟,孟昭杰,陈晗,陈立,赵珩.促吸收剂癸酸钠对黄连素在大鼠肠道吸收的促进作用[J].吉林大学学报(医学版),2011,37(1):35-40. |
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| 作者姓名： | 杜函泽 吕晓艳 杜红伟 孟昭杰 陈晗 陈立 赵珩 |
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| 作者单位： | 吉林大学白求恩医学院珠江医院眼科,吉林,长春,130021;吉林大学第一医院干部病房,吉林,长春,130021;南方医科大学珠江医院眼科,广东,广州,510515 |
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| 基金项目： | 吉林省科技厅高技术产业发展项目资助课题，吉林大学大学生创新性实验计划项目资助课题 |
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| 摘 要： | 目的:探讨黄连素(Ber)在大鼠肠道的吸收动力学,阐明癸酸钠(SC)对Ber在小肠段吸收的影响.方法:雄性Wistar大鼠建立在体肠段灌流模型,HPLC法测定不同浓度Ber(50、100和200 μmol·L-1)和Ber与质量浓度为0.2%SC合用在小肠的吸收情况;测定肠灌流液中乳酸脱氢酶(LDH)活性,观察SC对肠...
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| 关 键 词： | 癸酸钠 黄连素 大鼠 Wistar 小肠 吸收动力学 |
| 收稿时间： | 2010-07-12 |
Absorption enhancement of sodium caprate on berberine in intestine of rats |
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| DU Han-ze,LU Xiao-yan,DU Hong-wei,MENG Zhao-jie,CHEN Han,CHEN Li,ZHAO Heng.Absorption enhancement of sodium caprate on berberine in intestine of rats[J].Journal of Jilin University: Med Ed,2011,37(1):35-40. |
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| Authors: | DU Han-ze LU Xiao-yan DU Hong-wei MENG Zhao-jie CHEN Han CHEN Li ZHAO Heng |
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| Institution: | (1. Department of Pharmacology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,China；2.Department of Cadre Ward,First Hospital,Jilin University,Changchun 130021,China；3. Department of Ophthalmology,Pearl River Hospital,Guangzhou 510515,China ) |
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| Abstract: | Objective To observe the intestine absorption kinetics of berberine(Ber) in rats and the effects of sodium caprate(SC) on Ber in intestinal absorption.Methods Male Wistar rats were used for the experiment.The in situ circular perfusion model was used to investigate the effect of SC on the intestinal absorption of Ber.The concentration of Ber was detected with HPLC.The activity of LDH was measured to evaluate the toxic effect of SC on mucous membrane cells.Results The absorption of Ber in the small intestine... |
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| Keywords: | sodium caprate berberine rats Wistar intestine absorption kinetics |
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