系统性红斑狼疮患者血清增殖诱导配体水平的检测及其临床意义

目的：检测系统性红斑狼疮(SLE)和类风湿性关节炎(RA)患者血清中增殖诱导配体（APRIL）的水平，探讨APRIL水平与SLE患者临床指标的相关性及APRIL在SLE发病中的作用。方法：采用ELISA法检测SLE患者组(48例)、RA患者组(16例)和正常对照组(16例)血清APRIL水平，并与SLE活动指数（SLEDAI）及实验室指标进行对比分析。结果：SLE组和RA组血清APRIL水平高于正常对照组（P<0.01），SLE组高于RA组（P<0.01）。SLE组中抗Sm抗体阳性患者APRIL水平高
于阴性患者（ P<0.05）。抗U1-RNP抗体阳性患者APRIL水平高于阴性患者（ P<0.05），抗SSA /SSB抗体、抗ACL抗体、抗ds-DNA抗体阳性和阴性患者APRIL水平差异无统计学意义。SLE患者血清APRIL水平与其补体C3、C4呈负相关关系（r1=－0.819，P<0.01；r2=－0.549，P<0.01），与SLEDAI评分、免疫球蛋白、抗核抗体谱等免疫学指标无相关性。结论：APRIL在SLE患者中特异性升高，可能在狼疮发病中起重要作用;血清APRIL水平可能与SLE患者疾病活动程度有关联，但尚不能确定是否可作为疾病活动性指标。

Determination of a proliferation-inducing ligand in patients with systemic lupus erythematosus and its clinical significance

Objective To determine the serum levels of a proliferation-inducing ligand(APRIL) in patients with systemic lupus erythematosus(SLE) and rheumatoid arthritis(RA) and analyze its correlations with immunological parameters and its roles in the development of SLE.Methods The levels of APRIL in 48 patients with SLE,16 patients with RA and 16 healthy controls were determined by enzyme linked immunosorbent assay(ELISA),its correlations with SLEDAI and immunological parameters were analyzed.Results The serum level...