| 烟草烟雾对离体大鼠胸主动脉舒缩功能的影响 |
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| 引用本文： | 任志霞,张海涛,刘朝中,谈诚,黄丛春,张涛. 烟草烟雾对离体大鼠胸主动脉舒缩功能的影响[J]. 安徽医科大学学报, 2011, 46(7): 636-639 |
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| 作者姓名： | 任志霞 张海涛 刘朝中 谈诚 黄丛春 张涛 |
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| 作者单位： | 第四军医大学西京医院心血管内科,西安,710032;安徽医科大学空军临床学院心血管内科,北京,100142;航天医学工程研究所,北京,100094;安徽医科大学,合肥,230032 |
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| 摘 要： | 目的 观察烟草烟雾对大鼠离体胸主动脉环张力的影响,并探讨其作用机制.方法 建立大鼠吸烟模型,采用离体胸主动脉环灌流装置,观察短期大量吸烟(SS)、中期大量吸烟(MS)及长期大量吸烟(LS)对氯化钾(KCl)、苯肾上腺素(PE)诱导血管收缩的作用,以及对乙酰胆碱(Ach)舒张血管环的影响,同时观察N-硝基-L-精氨酸甲酯...
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| 关 键 词： | 主动脉 胸 血管收缩 血管舒张 一氧化氮 |
Effects of cigarette smoking on vasoconstriction and vasodilatation of thoracic aorta in rats |
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| Ren Zhixia,Zhang Haitao,Liu Chaozhong,et al. Effects of cigarette smoking on vasoconstriction and vasodilatation of thoracic aorta in rats[J]. Acta Universitis Medicinalis Anhui, 2011, 46(7): 636-639 |
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| Authors: | Ren Zhixia Zhang Haitao Liu Chaozhong et al |
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| Affiliation: | Ren Zhixia1,Zhang Haitao2,Liu Chaozhong2,et al |
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| Abstract: | Objective To investigate the effect of tension of thoracic aortas in smoking rats,and to explore its mechanism.Methods Rats models of smoking were established,and isolated rat thoracic aortic perfusion apparatus were used.Effects of short-term heavy smoking(SS),medium term heavy smoking(MS)and long-term heavy smoking(LS)on vasoconstriction induced by KCl,phenephrine(PE) were observed,as well as aceylcholine(Ach) on relaxation of vessel rings.The roles of preconditioning with NG-Nitro-L-Arginine Methyl Ester... |
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| Keywords: | aorta thoracic vasoconstriction vasodilation nitric oxide |
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