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| 左心室缺血再灌注肺损伤模型的建立 | |
| 引用本文： | 姬明丽,千智斌,宋晓荣,王煜霞. 左心室缺血再灌注肺损伤模型的建立[J]. 中国病理生理杂志, 2011, 27(7): 1453-1456. DOI: 10.3969/j.issn.1000-4718.2011.07.039 |
| 作者姓名： | 姬明丽 千智斌 宋晓荣 王煜霞 |
| 作者单位： | 1. 新乡医学院 病理生理教研室, 河南 新乡 453003; 2. 新乡医学院 机能学实验室, 河南 新乡 453003 |
| 摘 要： | 目的: 探讨建立左心室缺血再灌注肺损伤模型的方法。方法: 40只家兔随机分为模型组和对照组,模型组建立左心室缺血再灌注肺损伤模型,对照组不做模型。对比2组动物心电图、膈肌放电曲线、心肌和肺组织HE染色组织病理情况、肺组织透射电镜超微结构变化情况。结果: 模型组心肌出现缺血再灌注损伤表现,肺组织出现急性损伤表现,二者之间的变化呈相关性。结论: 此种左心室缺血再灌注肺损伤模型是一种可行可靠的动物模型。 |
| 关 键 词： | 左心室缺血再灌注 急性肺损伤 模型 动物 |
| 收稿时间： | 2010-11-11 |
An animal model of acute lung injury induced by left ventricular ischemia-reperfusion |
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| JI Ming-li,QIAN Zhi-bin,SONG Xiao-rong,WANG Yu-xia. An animal model of acute lung injury induced by left ventricular ischemia-reperfusion[J]. Chinese Journal of Pathophysiology, 2011, 27(7): 1453-1456. DOI: 10.3969/j.issn.1000-4718.2011.07.039 | |
| Authors: | JI Ming-li QIAN Zhi-bin SONG Xiao-rong WANG Yu-xia |
| Affiliation: | 1. Department of Pathophysiology, Xinxiang Medical College, Xinxiang 453003, China; 2. Functional Laboratory, Xinxiang Medical College, Xinxiang 453003, China |
| Abstract: | AIM: To establish a method of making acute lung injury model induced by left ventricular ischemia-reperfusion.METHODS: Forty New Zealand rabbits were randomly divided into model group(MG) and control group(CG).The left ventricular ischemia-reperfusion was established by ligaturing and loosing the anterior descending branch of the left coronary artery in the rabbits in MG group.The electrocardiogram,the phrenic nerve discharge curve,the ultrastructure and histological analysis of the lung tissues were compar... |
| Keywords: | Left ventricular ischemia-reperfusion Acute lung injury Models animal |
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