| 强直性脊柱炎KIR3DL1基因多态性及基因环境因素交互作用研究 |
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| 引用本文： | 张立,潘发明,葛锐,曾臻,段振华,王笙,李桂兴,徐胜前,徐健华,李建平,刘萍,邹延峰. 强直性脊柱炎KIR3DL1基因多态性及基因环境因素交互作用研究[J]. 安徽医科大学学报, 2011, 46(7): 669-671 |
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| 作者姓名： | 张立 潘发明 葛锐 曾臻 段振华 王笙 李桂兴 徐胜前 徐健华 李建平 刘萍 邹延峰 |
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| 作者单位： | 安徽医科大学公共卫生学院流行病与卫生统计学系,合肥,230032;安徽医学高等专科学校省遗传医学中心,合肥,230061;安徽医科大学公共卫生学院流行病与卫生统计学系,合肥,230032;安徽医科大学第一附属医院风湿免疫科,合肥,230022;安徽医学高等专科学校省遗传医学中心,合肥,230061 |
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| 基金项目： | 国家自然科学基金，安徽省自然科学基金，安徽省学术和技术带头人后备人选计划、安徽省财政厅年度计划资助基金、安徽省卫生厅医学科研基金 |
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| 摘 要： | 目的 探讨KIR3DL1基因单核苷酸多态性与强直性脊柱炎(AS)易感性的关系.方法 采用以自然人群为基础的病例对照研究设计,收集125例AS患者和94例对照进行研究,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的方法,对KIR3DL1基因rs1049150位点多态性进行检测.采用χ2检验分析基因多态性与A...
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| 关 键 词： | 脊柱炎,强直性 多态性,单核甘酸 |
Study on the polymorphism of KIR3DL1 gene and interaction of gene-environment in ankylosing spondylitis |
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| Zhang Li,,Pan Faming,Ge Rui,et al. Study on the polymorphism of KIR3DL1 gene and interaction of gene-environment in ankylosing spondylitis[J]. Acta Universitis Medicinalis Anhui, 2011, 46(7): 669-671 |
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| Authors: | Zhang Li Pan Faming Ge Rui et al |
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| Affiliation: | Zhang Li1,2,Pan Faming1,Ge Rui1,et al(1Dept of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei 230032,2Anhui Medical Genetics Center in Anhui Medical College,Hefei 230061) |
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| Abstract: | Objective To study the association of KIR3DL1 gene with susceptibility to ankylosing spondylitis(AS).Methods A case-control study was taken in this investigation.The samples included 125 AS patients and 94 B27-positive healthy controls.The SNP for KIR3DL1 was genotyped by PCR-RFLP.Furthermore,we also investigated the interaction of KIR3DL1(rs1049150)gene and risk environmental factors.Results We had not found the polymorphism of KIR3DL1(rs1049150)by comparing with AS patients and healthy controls.There had ... |
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| Keywords: | spondylitis ankylosing polymorphism single nucleotide |
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