| 蜂毒素对人肝癌细胞裸鼠移植瘤生长的影响及其部分机制 |
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| 引用本文： | 王朋景,李俊,黄艳,吴宝明.蜂毒素对人肝癌细胞裸鼠移植瘤生长的影响及其部分机制[J].安徽医科大学学报,2011,46(9):905-909. |
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| 作者姓名： | 王朋景 李俊 黄艳 吴宝明 |
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| 作者单位： | 安徽医科大学药学院,合肥,230032;安徽医科大学药学院,合肥,230032;安徽医科大学药学院,合肥,230032;安徽医科大学药学院,合肥,230032 |
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| 基金项目： | 安徽省自然科学基金，高校省级优秀青年人才基金，安徽省高校青年教师科研资助项目 |
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| 摘 要： | 目的 探讨蜂毒素对人肝癌HepG-2细胞株裸鼠移植瘤的抑制作用.方法 建立人肝癌HepG-2细胞裸鼠皮下移植瘤模型,随机分为模型组、蜂毒素组(1、2、4 mg/kg)和氟尿嘧啶 (5-FU,2 mg/kg) 组,各组腹腔注射给药10 d,用药结束后隔天处死动物.观察蜂毒素腹腔注射对人肝癌细胞在裸鼠体内生长的的影响,计算...
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| 关 键 词： | 蜂毒肽 肝肿瘤 实验性 |
Effect and partial mechanisms of melittin on human hepatocellular carcinoma cells xenograft in nude mice |
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| Wang Pengjing,Li Jun,Huang Yan,et al.Effect and partial mechanisms of melittin on human hepatocellular carcinoma cells xenograft in nude mice[J].Acta Universitis Medicinalis Anhui,2011,46(9):905-909. |
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| Authors: | Wang Pengjing Li Jun Huang Yan |
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| Institution: | Wang Pengjing,Li Jun,Huang Yan,et al(School of Pharmacy,Anhui Medical University,Hefei 230032) |
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| Abstract: | Objective To study the effects of melittin on the growth of human hepatocellular carcinoma HepG-2 cells xenograft in BALB/c nude mice and explore its possible mechanism of antitumor action in vivo.Methods The nude mice with HepG-2 cell xenografts were randomly divided into control group,melittin group(1,2,4 mg/kg),5-FU group(2 mg/kg),administered for 10 days.The mice were killed 2 days after treatment.The xenograft tumor growth in mice was measured after injection of melittin.Tumor volume,tumor weight and s... |
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| Keywords: | melittin liver neoplasms experimental |
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