原发性高血压患者血清C反应蛋白的变化

目的：观察原发性高血压（EH）患者血清C反应蛋白（CRP）的变化,探讨CRP与EH的关系及其临床意义。方法：运用酶联免疫吸附法（ELISA）测定100例EH患者和28例对照组人群的血清CRP,100例EH患者中,单纯EH41例,合并冠心病（CHD）59例;非极高危EH11例,极高危EH89例。41例单纯EH中,极高危EH30例,其中2级EH13例,3级EH17例;中年EH22例,老年EH19例。结果：（1）EH组血清CRP含量显著高于对照组（P〈0.05）;（2）3级EH组血清CRP含量显著高于2级组（P〈0.05）,2级EH组血清CRP含量显著高于对照组（P〈0.05）;EH极高危组血清CRP含量显著高于非极高危组（P〈0.05）,EH非极高危组血清CRP含量显著高于对照组（P〈0.05）;（3）老年EH组血清CRP含量显著高于中年组（P〈0.05）,中年组血清CRP含量显著高于对照组（P〈0.05）。结论：（1）CRP可能与EH有关;（2）CRP可能参与了EH的分级和危险分层;（3）CRP可能与EH患者的年龄有关。

Changes of Serum C-reactive Protein in Patients with Essential Hypertension and Its Clinical Importance

Objective： To observe the changes of serum C-reactive protein （CRP） in patients with essential hypertension （EH） and to study the relationship between CRP and EH, and its clinical significance. Methods： Circulating CRP concentrations of 100 patients with EH （experimental group, group E） and 28 patients with no EH （control group, group C） were measured with enzyme-linked immunosorbentassay （ELISA） method, and coronary angiography was operated on all of the patients. Results： CRP in patients of group E was significantly higher than that of group C （P 〈0.05） ; CRP in patients of grade 2 in group E was significantly higher than that of group C （ P 〈 0. 05 ） ; Within group E, CRP of grade 3 patients was obviously higher than that of grade 2 patients （P 〈 0.05）, and CRP of highest risk patients was markedly higher than that of non risk patients（P 〈0.05 ）, while CRP of non-high risk patients was statistically higher than that of patients in group C （ P 〈 0.05 ） ; CRP in older patients was higher than that in middle-aged patients which was higher than that of group C. Conclusions： （1）CRP might be correlated to EH; （2） CRP might participate the process of blood pressure grading and the delamination of risk factors; （3） There is some correlation between EH and patient age.