原发性网膜、肠系膜间质瘤的临床病理及免疫组织化学研究

为探讨网膜，肠系膜间质瘤临床病理，免疫组织化学特征，对8例网膜，肠系膜间质瘤作了临床病理形态学观察和免疫组织化学分析，而且所有肿瘤均获得随访资料。结果表明，肿瘤为单发结节，体积大，组织学上主要由具有哮酸性胞浆及核两端存在细胞浆空泡的梭形细胞构成，部分肿瘤可见上皮样细胞等平滑肌分化证据，免疫表型特特为：8例（100％）肿瘤C－kit均性，7例（87．5％）CD34阳性，6例（75％）SMA呈局灶性或散在阳性，2例恶性间质瘤p53,PCNA表面阳性，良性病例中1例PCNA低水平表达，结果提示，网膜，肠系膜间质瘤有其独立临床病理特征，免疫组化C-kit,CD34标记物对网膜，肠系膜间质瘤具有重要意义。

GASTROINTESTINAL PRIMARY STROMAL TUMOR IN OMENTUM AND MESENTERY : A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY

To study the clinicopathological and immunohistochemical characteristics of omental and mesenteric stromal tumor, 8 cases of stromal tumor were investigated, and followed up. The results showed that these tumors were solitary nodule, most were large. Histologically, cytoplasmic eosinophilia and perinuclear vacuolization were often seen in omental and mesenteric stromal tumor of spindle cell type. 3 cases showed epithelioid cytologic features. An immunohistochemical study showed that all the patients were C kit positive (100%),7 were CD34 positive, whereas 6 were SMA positive, positive expression of p53 and PCNA was found in 2 cases of malignant stromal tumor, Lower expression of PCNA was observed in 1 case of benign one.The results suggested that omental and mesenteric stromal tumors have distinct clinicopathological features, the expression of C kit and CD34 plays an important role in its diagnosis.