| CTD方案治疗难治或复发多发性骨髓瘤 |
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| 作者姓名： | Gao W An N Chen SL |
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| 作者单位： | 100020,首都医科大学附属北京朝阳医院血液科 |
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| 摘 要： | 目的应用环磷酰胺、沙立度胺及地塞米松(CTD)方案治疗难治或复发多发性骨髓瘤(MM)。方法20例难治或复发MM患者接受沙立度胺,100~200mg/d,口服持续应用;环磷酰胺,200~300mg.m-2.d-1,1~4d,静脉注射;地塞米松,20~40mg/d,1~4d,口服。4周为1个疗程。3个疗程后,若出现疗效或病情稳定则再连续应用3个疗程;若病情进展,则停止治疗。结果3个疗程后,13例(65%)患者显示治疗反应,其中9例患者获部分缓解,4例患者获微小缓解。而5例患者病情稳定,2例进展。对病情未进展的18例患者继续治疗3个疗程后再次评价,则部分缓解13例(65%),获微小缓解5例。结论CTD是一个具有较好治疗前景的方案。
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| 关 键 词： | 多发性骨髓瘤 沙立度胺 复发 难治 |
| 收稿时间： | 2005-07-25 |
| 修稿时间： | 2005-07-25 |
The effect of cyclophosphamide, thalidomide and dexamethasone combination therapy in relapsed/refractory multiple myeloma |
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| Gao W,An N,Chen SL.The effect of cyclophosphamide, thalidomide and dexamethasone combination therapy in relapsed/refractory multiple myeloma[J].Chinese Journal of Internal Medicine,2006,45(3):221-222. |
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| Authors: | Gao Wen An Na Chen Shi-lun |
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| Institution: | Department of Hematology and Oncology, Affiliated Beijing Chaoyang Hospital of Capital University of Medical Sciences, Beijing 100020, China. gaowenpingping@sohu.com |
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| Abstract: | OBJECTIVE: To investigate the effect of the combination of thalidomide, cyclophosphamide and dexamethasone for the treatment of relapsed/refractory multiple myeloma. METHODS: 20 relapsed/refractory multiple myeloma patients received thalidomide (200 mg/d), cyclophosphamide (300 mg.m(-2).d(-1), d1-4, every 4 weeks) and pulsed dexamethasone (20-40 mg/d, d1-4, every 4 weeks). RESULTS: After 3 cycles of therapy, 9 cases obtained partial remission (PR), 4 had minimal responses (MR), 5 were of no change and 2 had progressive disease. After 6 cycles of therapy, 13 patients achieved PR and 5 had MR. CONCLUSION: The combination of thalidomide, cyclophosphamide and dexamethasone is a promising treatment regime for relapsed/refractory multiple myeloma. |
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| Keywords: | Multiple myeloma Thalidomide Relapsed Refractory |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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