不同乙型肝炎疫苗预防接种效果比较

目的:比较不同乙型肝炎(乙肝)疫苗预防接种的效果。方法:将282例乙型肝炎疫苗预防接种对象随机分为重组乙肝疫苗(CHO细胞)组和重组乙肝疫苗(汉逊酵母)组,每组141例,比较两组人群的抗体阳转率和几何平均浓度。结果:汉逊酵母组抗体阳转率为95.7%,显著高于CHO细胞组的85.8%,几何平均浓度为(2463.7±149.6)IU/L,显著高于CHO细胞组的(1576.7±123.2)IU/L,组间差异均有统计学意义(P<0.05),两组患者接种期间无严重不良反应发生。结论:重组乙肝疫苗(汉逊酵母)预防接种效果好,安全性高,值得临床进一步推广使用。

Comparison of immunization effect of different hepatitis B vaccine

Objective To compare immunization effect of different hepatitis B vaccine.Methods 282 cases of hepatitis B vaccination subjects were randomly divided into recombinant hepatitis B Vaceine（CHO cell） group and recombinant hepatitis B vaccine（hansenula polymorpha） group,141 cases in each group,compared the antibody positive conversion rate and geometric mean concentration.Results The antibody positive conversion rate of cases in hansenula polymorpha group was 95.7%,significantly higher than that in CHO ceU（85.8%）,the geometric mean concentration was （2 463.7 ± 149.6 ） IU/L,significantly higher than that in CHO cells group（1 576.7 ± 123.2） IU/L,the differences between two groups were significant（P 〈 0.05）,no serious adverse reactions occurred during inoculation.Conclusion The vaccination effect of recombinant hepatitis B vaccine（hansenula polymorpha） is good,and has high safety, it is worthy of further clinical application.