血清食物特异性IgG与慢性荨麻疹相关性研究

目的探讨慢性荨麻疹发病与血清中食物特异性IgG抗体的关系。方法应用酶联免疫吸附试验（ELISA）检测111例慢性荨麻疹患者（慢性荨麻疹组）血清中食物特异性IgG抗体水平，并与30例健康受试者（对照组）资料进行对比研究。结果111例慢性荨麻疹患者中，食物特异性IgG抗体阳性79例（阳性率为71．17％），与对照组阳性率（43．33％）比较，差异有统计学意义（X2=8．071，P〈0．01）。且慢性荨麻疹组以鸡蛋特异性IgG抗体阳性率最高（51．35％），其次是虾（43．24％）、牛奶（38．74％）、螃蟹（34．23％）、大豆（27．93％），慢性荨麻疹组鸡蛋、虾、螃蟹、鳕鱼、大豆特异性IgG抗体阳性率与对照组比较，差异有统计学意义（P〈0．05）。结论食物特异性IgG抗体与慢性荨麻疹发病具有相关性，血清食物特异性IgG水平检测对慢性荨麻疹的预防和治疗具有重要意义。

The correlation research on food-specific IgG in human serum and chronic urticaria

Objective To explore the relationship between specific immunoglobulin G（IgG） antibody from serum food and chronic urticaria. Methods Enzyme linked immunosorhent assay （ELISA） was applied to detect the food-specific IgG antibody level in serum of 111 patients with chronic urticaria （chronic urticaria group ）, and 30 healthy people （control group ） were se- lected for comparative study. Results Among the 111 eases of chronic urticaria, 79 cases were with positive food-specific IgG antibody in serum with the positive rate of 71.17%, comparing with the positive rate in control group （43.33%）, the difference had statistical significance （X2=8.071, P〈0.01 ）. In chronic urticaria group, the highest positive rate （51.35% ） appeared in the egg test, followed by shrimp （43.24%）, milk （ 38.74% ）, crab （ 34.23% ） and soybean （27.93%）. Compared with the control group, the positive rate of specific IgG antibody in egg, shrimp, crab, cod and soybean in chronic urticaria group had statistically signifi- cant difference （P〈O.05）. Conclusion Food-specific IgG antibody has a relationship with chronic urticaria, and it is important to detect food-specific IgG level in serum to improve the prevention and treatment of chronic urticaria.