紫杉醇联合顺铂新辅助化疗治疗局部晚期宫颈癌的疗效观察

目的观察紫杉醇联合顺铂新辅助化疗治疗局部晚期宫颈癌的临床疗效。方法 77例局部晚期宫颈癌患者随机分为两组,观察组(n=37例)采用紫杉醇联合顺铂新辅助化疗联合手术治疗,对照组(n=40例)采用单纯手术治疗。比较两组临床疗效、淋巴结阳性率、阴道切缘阳性率、宫旁累及率和脉管浸润率等情况。结果两组患者在FIGO分期、肿瘤直径、病理分级及病理学类型等方面比较无显著差异(P0.05);观察组术前化疗总有效率为73.0%,两组手术时间及失血量比较无显著差异(P0.05),观察组阴道切缘阳性率、淋巴结阳性率、宫旁累及率及脉管浸润率明显低于对照组(P0.05)。结论紫杉醇联合顺铂术前新辅助化疗可降低局部晚期宫颈癌患者术后阴道切缘阳性率、淋巴结阳性率、宫旁累及率及脉管浸润率,值得临床推广应用。

The curative effect of neoadjuvant chemotherapy with paclitaxel and cisplatin in treatment of locally advanced cervical cancer

Objective To observe the clinical effect of neoadjuvant chemotherapy with paclitaxel combined with cisplatin in treatment of patients with locally advanced cervical cancer. Methods A total of 77 patients with locally advanced cervical cancer were randomly divided into two groups, patients in observation group （ n = 37） were treated by neoadjuvant chemotherapy with paclitaxel and cisplatin combined with opera- tion, and patients in control group （ n = 40 ） were treated with operation. The clinical efficacy, positive rate of metastasis in lymph nodes, and pos- itive rate of vaginal margin, rate of parametrial involvement and rate of vascular invasion were compared between these 2 groups. Results There was no significant difference between these two groups in FIGO stage, tumor size, pathological grade and pathological types （ P 〉 0.05 ）. The total effective rate of chemotherapy in observation group before operation was 73.0%, and there was no significant difference between these two groups in operating time and blood loss （ P 〉 0.05 ）, the positive rate of vaginal cut margin, rate of positive lymph nodes, rate of parametrial in- volvement and rate of vascular invasion in patients of observation group were significantly lower than those of control group （ P 〈 0.05 ）. Conclu- sion The treatment by neoadjuvant chemotherapy with paclitaxel combined with cisplatin in patients with locally advanced cervical cancer can re- duce the rate of positive vaginal margin, rate of positive lymph nodes, rate of parametrial involvement and rate of vascular invasion. Hence it is worthy to be clinically applied.