| CD_7~+的急性髓细胞性白血病的临床意义 |
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| 引用本文： | 刘秀娥.CD_7~+的急性髓细胞性白血病的临床意义[J].临床医药实践,2003,12(4):243-245. |
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| 作者姓名： | 刘秀娥 |
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| 作者单位： | 山西医科大学第二医院,山西,太原,030001 |
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| 基金项目： | 山西省卫生厅青年科研基金资助,课题编号 970 2 7 |
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| 摘 要： | 目的 :观察和探讨 CD7+ 的急性髓细胞性白血病 (AML )表达特征及它们对 AML患者预后的影响。方法 :采用间接免疫荧光法和流式细胞仪对 2 75例初诊的 AML患者进行了免疫表型检测 ,并对淋系分化抗原阳性表达率加髓系分化抗原阳性表达率大于 10 0 %患者的白血病细胞用流式细胞仪做双标记分析。结果 :2 75例 AML患者中 ,3 6例表达淋系分化抗原 CD7(占 13 .1% ) ;诱导化疗疗效方面 ,在同等化疗强度的基础上 ,CD34+ CD7+ AML患者的缓解率明显低于 CD34- CD7- AML 患者 (P<0 .0 5 )。结论 :CD7+ AML 的表达具有复杂性、异质性 ,属于一种预后不良的临床亚型 ,应进一步探索针对性的治疗策略
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| 关 键 词： | 免疫表型 淋系 急性髓细胞性白血病 预后 |
| 文章编号： | 1671-8631(2003)04-0243-03 |
| 修稿时间： | 2003年3月3日 |
Clinical significance of CD7+ in acute myeloid leukemia |
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| LIU Xiu-e.Clinical significance of CD7+ in acute myeloid leukemia[J].Proceeding of Clinical Medicine,2003,12(4):243-245. |
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| Authors: | LIU Xiu-e |
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| Abstract: | Objective:To further explore the expression of CD 7 + in acute myeloid leukemia(AML)and its impact of on clinical prognosis of patients with AML.Methods:Using indirect immmunofluorescence assay and immunophenotyping was performed in 275 patients with AML.Leukemic cells co-expressing lymphoid and myeloid associated antigens were analysed by dual-color flow cytometry when the two expressing percentages plus more than 100 %.Results:Thirty-six in 275 patients expressed CD 7(13.1 %).Achieve CR 1 is not different.The remission rate(CR) in CD 34 +CD 7 + patients with AML was Lower than CD 34 -CD 7 - patients with AML(P<0.05).Conclusion:Expression of CD 7 + AML showed complexity and heterogeneity,CD 7 +AML patients predict a poor prognosis.Therapic desingn direct to this adverse clinical subtype remains to be explored. |
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| Keywords: | immunophenotyping lymphoid acute myeloicl leukemia prognosis |
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