| 内皮素-1对膀胱癌环氧化酶-2表达的影响及意义 |
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| 引用本文： | 高敏,曾学明. 内皮素-1对膀胱癌环氧化酶-2表达的影响及意义[J]. 现代中西医结合杂志, 2010, 19(36) |
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| 作者姓名： | 高敏 曾学明 |
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| 作者单位： | 江苏省昆山市中医医院,江苏,昆山,215300 |
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| 摘 要： | 目的研究内皮素-1(ET-1)对膀胱癌细胞株T24环氧化酶-2(COX-2)表达的影响及意义。方法应用不同浓度(0μg/L、10μg/L、100μg/L)的ET-1刺激T24细胞6 h后,用RT-PCR和Western-blot检测其COX-2 mRNA和蛋白水平变化。结果 ET-1可使T24细胞COX-2的mRNA和蛋白表达明显升高,与对照组比较有显著性差异(P均0.05)。结论 ET-1可使T24细胞COX-2的表达上调,这种调节可能在膀胱癌的复发和进展中发挥重要作用。
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| 关 键 词： | 内皮素-1 环氧化酶-2 膀胱癌 |
Effect and clinic significance of endothelin-1 on cyclooxygenase-2 expression in bladder cancer |
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| Gao Min,Zeng Xueming. Effect and clinic significance of endothelin-1 on cyclooxygenase-2 expression in bladder cancer[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2010, 19(36) |
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| Authors: | Gao Min Zeng Xueming |
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| Abstract: | Objective It is to observe the influence and clinic significance of Endothelin-1 on the cyclooxygenase-2(COX-2) expression in bladder cancer T24 cell line.Methods The expression of COX-2 in the T24 cell was detected by RT-PCR and Western blot assay after they were stimulated with Endothelin-1(0μg/L,10μg/L,100μg/L) for 6h.Results The COX-2 expression in T24 cell was significantly increased after exposure to ET-1 for 6 h(P<0.05).Conclusion Endothelin-1 can induce upregulation of COX-2 in T24 cell and the regulation maybe play an important role in the recurrence and development of bladder cancer. |
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| Keywords: | Endothelin-1 Cyclooxygenase-2 bladder cancer |
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