| HPLC法同时测定复方芸归颗粒中松果菊苷、阿魏酸和柚皮苷含量 |
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| 引用本文： | 张霞,王荣,侯延辉,徐立生.HPLC法同时测定复方芸归颗粒中松果菊苷、阿魏酸和柚皮苷含量[J].西北药学杂志,2010,25(6):403-405. |
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| 作者姓名： | 张霞 王荣 侯延辉 徐立生 |
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| 作者单位： | 1. 宁夏医科大学药学院,宁夏,银川,750004;宁夏回药现代化工程技术研究中心,宁夏,银川,750004
2. 宁夏医科大学中医学院,宁夏,银川,750004 |
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| 基金项目： | 宁夏医科大学特殊人才启动项目 |
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| 摘 要： | 目的建立高效液相色谱法同时测定复方芸归颗粒中松果菊苷、阿魏酸和柚皮苷含量的方法。方法色谱柱:ThermoODS-2 HYPERSIL C18柱(250 mm×4.6 mm,5μm);流动相:乙腈-0.1%磷酸溶液梯度洗脱;流速:1.0 mL.min-1;检测波长:310 nm;柱温:30℃。结果松果菊苷、阿魏酸和柚皮苷分别在42.4～530,5.72～71.5和38.4～480 mg.L-1范围内线性关系良好;平均回收率分别为98.2%,94.6%和96.5%。结论所建立的方法快速简便、灵敏,重现性良好,可用于复方芸归颗粒的质量控制。
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| 关 键 词： | 高效液相色谱 复方芸归颗粒 松果菊苷 阿魏酸 柚皮苷 |
Simultaneous determination of echinacoside,ferulic acid and naringin in FuFang YunGui Granules by HPLC |
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| ZHANG Xia,WANG Rong,HOU Yanhui,XU Lisheng.Simultaneous determination of echinacoside,ferulic acid and naringin in FuFang YunGui Granules by HPLC[J].Northwest Pharmaceutical Journal,2010,25(6):403-405. |
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| Authors: | ZHANG Xia WANG Rong HOU Yanhui XU Lisheng |
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| Institution: | ZHANG Xia1,3,WANG Rong2,HOU Yanhui1,XU Lisheng1,3(1.College of Pharmacy,Ning Xia Medical University,Yinchuan 750004,China,2.College of Chinese Medicine,Ning Xia medical university,3.Ning Xia Engineering and Technology Research Center for Modernization of Hui Medicine,4.Ning Xia Pharmaceutical Institute,Yinchuan 750004) |
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| Abstract: | Objective To establish an HPLC method for simultaneous determination of echinacoside,ferulic acid and naringin in FuFang YunGui Granules.Methods The separation was performed on a Thermo ODS-2 HYPERSIL C18（250 mm ×4.6 mm,5 μm） column with gradient elution.Mobile phase was acetonitrile and 0.1% phosphoric acid at a flow rate of 1.0 mL·min-1.The UV detector was set at 310 nm and the column temperature was 30 ℃.Results The method had good linear relationship in the ranges of 42.4-530 mg· L-1 for echinacoside,5.72-71.5 mg· L-1 for ferulic acid,and 38.4-480 mg· L-1 for naringin.The average recoveries were 98.2%,94.6%,and 96.5%,respectively.Conclusion The method is fast,simple,sensitive and can be used for quality control of Fufang YunGui Granules. |
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| Keywords: | HPLC FuFang YunGui Granules echinacoside ferulic acid naringin |
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