Effect of the season on lipid peroxidation in the myocardium of rats with different resistance to hypoxia |
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| Authors: | M L Khachatur'yan V M Gukasov P G Komarov L B Pirogova M V Bilenko |
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| Institution: | (1) Department of Experimental Biological Models, Russian State Medical University, Moscow;(2) Department of Mathematical Methods, Russian State Medical University, Moscow;(3) Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Lipid peroxidation and the antioxidant system of the myocardium of adult male Wistar rats with low and high resistance to
acute hypoxia tested by “raising” to an altitude of 11.5 km are studied in winter and in summer. It is found that the winter
season is a mild stressor inducing changes in the myocardial antioxidant system and lipid peroxidation which are similar to
those observed at the early stages of catecholamine stress in the summer season. In both cases alterations are more pronounced
in low-resistance than in high-resistance rats. In winter, in low-resistance rats the intensity of lipid peroxidation and
the activity of the antioxidant system are lower, while the ratio of their parameters (chemiluminescence data) is higher.
At the same time, the levels of thiobarbituric acid-reactive substances are higher in winter in both groups. The relationship
between the studied parameters and the resistance of rats to hypoxia is more obvious in winter than in summer, i.e., it is
season-dependent and is also more pronounced in catecholamine stress.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, Nolo 7, pp. 87–90, July, 1995
Presented by N. A. Agadzhanyan, Member of the Russian Academy of Medical Sciences |
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| Keywords: | lipid peroxidation antioxidant system hypoxia low resistance high resistance season |
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