A case of systemic lupus erythematosus complicated by progressive multifocal leukoencephalopathy: case report and review of the literature |
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| Authors: | Tohru Akahoshi Mamoru Ishikawa Michio Takahashi Naho Sekiyama Kazuko Hasegawa Kiyoharu Watanabe Yoshihiro Ishihara Hirobumi Kondo |
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| Affiliation: | 1. Departments of Internal Medicine and Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, 228, Sagamihara, Kanagawa, Japan
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| Abstract: | Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system caused by an opportunistic infection of the JC virus. PML is known to occur in immunocompromised patients. A patient with systemic lupus erythematosus (SLE) who developed PML during i.v. cyclophosphamide and methylprednisolone pulse therapy is described. The pertinent literature relating to complication of SLE by PML is discussed. |
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