| 脐血LAK细胞活性的诱导及调节 |
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| 引用本文： | 侯桂华,曹容华,姜启海,吴光照,周亚滨. 脐血LAK细胞活性的诱导及调节[J]. 山东大学学报(医学版), 1992, 0(2) |
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| 作者姓名： | 侯桂华 曹容华 姜启海 吴光照 周亚滨 |
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| 作者单位： | 山东医科大学微生物学教研室，山东医科大学微生物学教研室，山东医科大学微生物学教研室，山东医科大学微生物学教研室，山东医科大学微生物学教研室 |
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| 摘 要： | 应用~(51)Cr释放试验研究了人脐血LAK细胞对K562细胞及Raji细胞的杀伤率,以及OK-432、干酪乳酸杆菌对脐血LAK细胞的调节作用。结果表明,rIL-2可诱导人脐血淋巴细胞产生LAK细胞活性,杀伤Raji细胞的能力由10%增至50%,对K562细胞的杀伤力也明显增强,统计学处理有显著意义。培养4天的LAK细胞杀伤力最强,杀伤率随效靶比例的增加而增强。OK-432及干酪乳酸杆菌均能增强rIL-2诱导的脐血LAK细胞的抗瘤活性。
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| 关 键 词： | 淋巴因子激活杀伤细胞 胎血 OK-432 干酪乳杆菌 肿瘤细胞 |
INDUCTION AND REGULATION OF LAK ACTIVITIES FROM UMBILICAL BLOOD |
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| Hou Guihua,et al Dept.of Microbiology of Shandong Medical University. INDUCTION AND REGULATION OF LAK ACTIVITIES FROM UMBILICAL BLOOD[J]. Journal of Shandong University:Health Sciences, 1992, 0(2) |
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| Authors: | Hou Guihua et al Dept.of Microbiology of Shandong Medical University |
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| Abstract: | The LAK cells killing activity of human umbilical blood was studied by ~(51)Cr releasing test.The result reveals that LAK killing activity can be induced from umbilical blood.After 4 days culture,the LAK ac-tivities to Raji cells were increased from 10% to 50%,the NK activities also increased(P<0.05).We also studied the effects of OK-432 and lacto-bacillus on LAK activities of umbilical blood,the results showed that these two bacterial regulators both enhanced the LAK activities.This results suggested that the human umbilical blood may be a better source of LAKcells for tumor treatment and OK-432 or lactobacillus casei may be the better cofactors for rIL-2 in induction of LAK activities. |
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| Keywords: | LAK cells Fetal blood Picibanil Lactobacillus casei Neoplasm cells |
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