Distribution of substance P receptor binding in dorsal column nuclei of rat, cat, monkey and human |
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Authors: | Harris D Schwark Michael J Petit Jannon L Fuchs |
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Abstract: | In the present study, substance P receptor binding was localized in the dorsal column nuclei (DCN) of the rat, cat, monkey, and human. Bolton–Hunter-labeled 125I]substance P binding was most concentrated in the cell nests of the core region, but was present throughout the DCN of each species. The distribution of substance P receptors may reconcile apparent mismatches between the widespread responsiveness of DCN neurons to substance P and the restricted distribution of substance P containing afferents. |
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Keywords: | Dorsal column nucleus Human Somatosensory Substance P receptor NK-1 receptor |
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