Cascade afteraction of delta sleep-inducing peptide in rats |
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| Authors: | K. V. Sudakov J. P. Coghland A. V. Kotov R. M. Salieva Yu. V. Polyntsev E. V. Koplik |
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| Affiliation: | (1) Laboratory for Physiology of Emotions and Emotional Stress and Laboratory for Physiology of Motivations, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow;(2) Howard Florey Institute of Experimental Physiology and Medicine, Australia |
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| Abstract: | Delta sleep-inducing peptide is found to alter markedly the levels of substance P, β-endorphin, and corticosterone in the hypothalamus and blood plasma of rats, suggesting that the long-lasting stress-mitigating effects of this peptide are due to the considerable changes it causes in the content of other oligopeptides and hormones, involving them in various processes. Thus, DSIP itself appears to act only as a trigger, initiating a cascade of interdependent molecular reactions that correlate with the degree of resistance to stress. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N o 1, pp. 6–9, January, 1995 |
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| Keywords: | delta sleep-inducing peptide aftereffects substance P β -endorphin corticosterone resistance to emotional stress |
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