窒息性心脏骤停大鼠呼吸变化特点与复苏疗效的关系

目的:了解在诱导大鼠窒息性心脏骤停过程中,呼吸变化的特点与心肺复苏疗效的关系.方法:对60只SD大鼠夹闭气管诱导窒息性心脏骤停,窒息10 min后开始常规心肺复苏并给予大鼠静注肾上腺素0.04 mg/kg 1次,10 min内未恢复自循环者放弃复苏.比较复苏成功组和复苏失败组大鼠在诱导窒息性心脏骤停过程中心电图(ECG)和呼吸变化特点的差异.结果:60只大鼠中有48只复苏成功,12只复苏失败.两组大鼠在窒息前的各种参数比较无明显差异,在诱导心脏骤停过程中,心电图变化也无显著差异,但复苏成功组大鼠发生喘息样呼吸的概率明显高于复苏失败组(分别为31.3%和0%,P＜0.05).结论:在诱导窒息性心脏骤停过程中,喘息样呼吸的出现可能有助于减轻重要脏器缺血缺氧性损伤,有利于提高心肺复苏成功率.

THE RELATIONSHIP BETWEEN THE OUTCOME OF CARDIOPULMONARY RESUCITATION AND THE CHANGES OF RESPIRATION IN ASPHYXIA CARDIAC ARREST RAT MODEL

Objective: To identify whether the outcome of cardiopulmonary resuscitation is associated with the changes of respiration during induction of asphyxia cardiac arrest. Methods: Cardiac arrest was induced by means of asphyxia in sixty Sprague-Dawley rats of both sexes. Ten min after asphyxia cardiopulmonary resuscitation was initiated and the animals were given a dose of epinephrine (0.04/kg, iv) at the same time. Failure to restore spontaneous circulation within 10 minutes resulted in discontinuation of resuscitation efforts. The differences of the changes of electrocardiogram and respiration during induction of cardiac arrest were compared between the resuscitated and unresuscitated animals. Result: 48 of 60 animals were successfully resuscitated and 12 of 60 animals failed to be resuscitated in the present study. There was no significant difference regarding the baseline variables before asphyxia and the changes of electrocardiogram during induction of cardiac arrest between resuscitated and unresuscitated animals. However, the incidents of gasp in resuscitated animals were much higher than those in unresuscitated animals (31.3% in resuscitated group and 0% in unresuscitated group respectively,P<0.05). Conclusion: Gasp may mitigate the anoxic injury of vital organisms during induction of asphyxia cardiac arrest and consequently facilitate the animals with gasp to restore spontaneous circulation during CPR.