| 商陆皂甙甲抑制大鼠腹腔巨噬细胞释放血小板活化因子 |
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| 引用本文： | 方军,郑钦岳. 商陆皂甙甲抑制大鼠腹腔巨噬细胞释放血小板活化因子[J]. 药学学报, 1991, 26(10): 721-724 |
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| 作者姓名： | 方军 郑钦岳 |
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| 作者单位： | 第二军医大学药学院药学理教研室,上海200433 |
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| 摘 要： | 卡西霉素(A23187)刺激大鼠腹腔巨噬细胞释放血小板活化因子(PAF),用洗涤血小板聚集的方法测定,证明商陆皂甙甲在0.1～100μmol/L浓度范围内及所试的时间范围内,呈剂量及时间依赖性抑制大鼠腹腔巨噬细胞释放PAF:商陆皂甙甲可能就是通过抑制体内PAF生成而起抗炎作用的。
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| 关 键 词： | 商陆皂甙甲 血小板活化因子 卡西霉素 巨噬细胞 |
| 收稿时间： | 1990-10-15 |
INHIBITORY EFFECT OF ESCULENTOSIDE A ON PLATELET ACTIVATING FACTOR RELEASED FROM CALCIMYCIN INDUCED RAT PERITONEAL MACROPHAGES. |
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| J Fang and QY Zheng. INHIBITORY EFFECT OF ESCULENTOSIDE A ON PLATELET ACTIVATING FACTOR RELEASED FROM CALCIMYCIN INDUCED RAT PERITONEAL MACROPHAGES.[J]. Acta pharmaceutica Sinica, 1991, 26(10): 721-724 |
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| Authors: | J Fang and QY Zheng |
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| Affiliation: | Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai. |
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| Abstract: | Platelet activating factor (PAF) is a kind of inflammatory mediator. We used the method of aggregation of washed rabbit platelet to study the effect of esculentoside A (EsA) on the release of PAF from calcimycin (A23187)stimulated rat peritoneal macrophages and found that the release of PAF was inhibited by EsA in a time and dose dependent manner. The IC50 of EsA for the inhibition of PAF release was 1.5 mumol/L. Under the same condition, the release of PAF was also inhibited by mepacrine at 100 mumol/L. The results indicate that EsA is a potent inhibitor of PAF synthesis in rat peritoneal macrophages. |
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| Keywords: | Platelet activating factor (PAF) Calcimycin (A3187)) Macrophage Esculentoside A (EsA) |
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