| 美欧卡霉素胃内滞留漂浮型缓释片的制备及药代动力学研究 |
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| 引用本文： | 刁勇,屠锡德. 美欧卡霉素胃内滞留漂浮型缓释片的制备及药代动力学研究[J]. 药学学报, 1991, 26(9): 695-700 |
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| 作者姓名： | 刁勇 屠锡德 |
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| 作者单位： | 中国药科大学药剂学教研室,南京210009;*1990届硕士研究生 |
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| 摘 要： | 本文根据流体动力学平衡药物控释系统的设计原理,制备了美欧卡霉素胃内滞留漂浮型缓释片(简称MOM-HBS)。该片剂由缓释、速释两种颗粒压制而成,其胃内滞留时间长达7h以上,明显长于普通片(3～4h)。体外溶出符合一级动力学过程(Kr=0.1619h-1).体内血约浓度经时曲线平缓持久,达到良好的缓释效果。体内外实验数据有显著的相关性(P<0.001),相对生物利用度较日本产干糖浆有明显提高。
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| 关 键 词： | 美欧卡霉素 缓释片剂 药代动力学 γ-闪烁照像技术 |
| 收稿时间： | 1990-07-09 |
DEVELOPMENT AND PHARMACOKINETIC STUDY OF MIOCAMYCIN SUSTAINED-RELEASE TABLET REMAINING-FLOATING IN STOMACH |
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| Y Diao and XD Tu. DEVELOPMENT AND PHARMACOKINETIC STUDY OF MIOCAMYCIN SUSTAINED-RELEASE TABLET REMAINING-FLOATING IN STOMACH[J]. Acta pharmaceutica Sinica, 1991, 26(9): 695-700 |
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| Authors: | Y Diao and XD Tu |
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| Affiliation: | Department of Pharmaceutics, China Pharmaceutical University, Nanjing. |
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| Abstract: | A novel sustained-release tablet of miocamycin was developed based on the hydrodynamically balanced controlled drug delivery system (HBS). It was prepared to contain fast-release and sustained-release granules. The gamma-scintiphotographic study after oral ingestion showed that MOM-HBS remained in human stomach for more than 7 hours, much longer than the conventional tablet (3-4 h). The in vitro release characteristics showed basically first-order kinetics (Kr = 0.1619 h-1). The serum concentration-time course of MOM-HBS exhibited typical sustained-release characteristics. Moreover, The percentage of drug released in vitro versus the percentage of drug released in vivo of MOM-HBS indicated excellent linearity. Its relative bioavailability was increased greatly compared with MOM dry syrup produced in Japan. |
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| Keywords: | Sustained release tablet Pharmacokinetics γ-Scintiphoto technique Miocamycin |
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