c-myc、PCNA、Fas在成骨性肿瘤中的表达

探索ｃ－ｍｙｃ、ＰＣＮＡ、Ｆａｓ表达与骨性肿瘤分化的关系。方法：采用免疫组织化学方法对骨肉瘤骨化性纤维瘤，骨纤维结构不良，正常骨痂进行ｃ－ｍｙｃ、ＰＣＮＡ，Ｆａｓ蛋白测定，与肿瘤组织学分级、细胞分化、核丝分裂比较分析。

Expression of c-myc, PCNA and Fas protein in osteogenic tumour

Objective:To investigate the relationship between osteogenic tumour differentiation and expression of cmyc,PCNA and Fas proteinMethods:The expression of cmyc,PCNA and Fas protein were examined immunohistologically in osteosarcoma, ossifying fibroma, fibrous dysplasia of bone and normalbone callusThe results were compared with the histological grading of tumour, cellular differentiation, mitosisResults: The positive expression of PCNA and cmyc protein in nuclei was associated with poorly differentiated tumours; the positive expression of Fas and cmyc protein in cytoplasms was consistent with welldifferentiated tumours Conclusion:The high expression of PCNA protein was important index of the active proliferation of tumour cells; the expression of cmyc protein in cytoplasm was closely related to the differentiation of tumour cells, and its high expression could not represent the active proliferation of tumour cells