乙型肝炎病毒前S1抗原在核苷类药物抗病毒治疗上的意义

目的 研究HBV前S1抗原(Pre-S1)在指导核苷(酸)类药物抗病毒治疗上的意义.方法 将HBeAg阳性患者经拉米夫定治疗获得完全应答并维持疗效6个月以上停药者以Pre-S1是否阳性分成两组,比较两组的远期疗效.结果 Pre-S1阴性组一年、二年远期持续应答率分别为80%、21.05%,差异有统计学意义(P＜0.01).阳性组患者一年、二年远期持续应答率分别为65%、10.53%,差异有统计学意义(P＜0.01).结论 检测Pre-S1可作为判断慢性乙型肝炎患者经核苷(酸)类药物治疗完全应答后远期疗效和预后的重要指标.

Significance of Pre-S1 antigen detection in evaluation of antiviral therapy by nucleotide analogs

Objective To evaluate the significance of HBV Pre-S1 antigen detection in clinical evaluation of antiviral therapy by nucleotide analogs .Method HBeAg positive patients which had combined complete response and sustained for 6 months after lamivudine therapy were divided into two groups according Pre-S1 detection and their therapeutic effect was compared.Results The response rates of one year and two year of HBV Pre-S1 antigen positive and negative were 80%and 21.05% respectively,and showed statistical difference(P＜0.01).The response rates of one year and two year of HBV Pre-S1 antigen negative were 65% and 10.53% respectively,and showed statistical difference(P＜0.01).Conclusions The detection of HBV Pre-S1 antigen may become an index that iudges long-term effect of chronic hepatitis patients after nucleotide analogs therapy.