| 红细胞生成素治疗前后肾性贫血患儿网织红细胞参数变化情况及临床意义 |
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| 引用本文： | 李启亮,徐樨巍,宋文琪,张清秀,宋敏.红细胞生成素治疗前后肾性贫血患儿网织红细胞参数变化情况及临床意义[J].上海医学检验杂志,2009(6). |
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| 作者姓名： | 李启亮 徐樨巍 宋文琪 张清秀 宋敏 |
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| 作者单位： | 北京儿童医院检验中心; |
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| 摘 要： | 目的探讨红细胞生成素(EPO)治疗前后肾性贫血患儿网织红细胞参数变化情况及临床意义。方法采用Beckm an cou lter LH 750全自动血液分析仪及Beckm an LX20全自动生化分析仪,检测EPO治疗前65例慢性肾功能不全不同病期患儿和65名正常对照的红细胞(RBC)计数、血红蛋白(Hb)含量、网织红细胞百分比(Ret%)、网织红细胞不成熟度(IRF)和平均网织红细胞体积(MRV),同时检测其血清肌酐(Cr)和尿素氮(BUN)含量,并进行比较分析;比较EPO治疗前、后肾性贫血患儿Ret%、RBC、Hb、IRF、MRV等参数的变化。结果EPO治疗前,氮质血症组和肾功能衰竭组的Ret%较对照组均有升高,但IRF值基本正常或略低;经过EPO治疗后肾功能不全患儿的贫血状态明显得到改善,IRF值和MRV值明显升高,IRF值升高的程度比Ret%更加明显。结论Ret参数尤其是IRF值的检测,有助于了解肾性贫血患儿的骨髓增生程度和红系的生长情况。
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| 关 键 词： | 患儿 慢性肾功能不全 贫血 网织红细胞 红细胞生成素 |
The changes of reticulocyte indices of renal anemia children treated with erythropoietin and its clinical significance |
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| LI Qiliang,XU Xiwei,SONG Wenqi,ZHANG Qingxiu,SONG Min..The changes of reticulocyte indices of renal anemia children treated with erythropoietin and its clinical significance[J].Shanghai Journal of Medical Laboratory Sciences,2009(6). |
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| Authors: | LI Qiliang XU Xiwei SONG Wenqi ZHANG Qingxiu SONG Min |
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| Abstract: | Objective To study the changes of reticulocyte indices of renal anemia children who accepted the treatment with erythropoietin(EPO) and its clinical significance.Methods Red blood cell(RBC),hemoglobin(Hb) and reticulocytes(Ret%),immature retivulocyte fraction(IRF),mean reticulocyte volumc(MRV) of peripheral blood were detected by Beckman coulter LH 750 hematology analyzer;creatinine(Cr) and blood urea nitrogen(BUN) were detected by Beckman LX20 biochemistry analyzer.The results were compared with 65 healthy... |
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| Keywords: | Children Chronic renal inadequacy Anemia Reticulocyte Erythropoietin |
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