| 培多普利对自发性高血压大鼠心室重塑过程中左室心肌细胞凋亡和Bcl2、BaX基因表达的影响 |
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| 引用本文： | 黄恺,戴闺柱. 培多普利对自发性高血压大鼠心室重塑过程中左室心肌细胞凋亡和Bcl2、BaX基因表达的影响[J]. 华中科技大学学报(医学版), 2002, 31(1): 40-43 |
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| 作者姓名： | 黄恺 戴闺柱 |
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| 作者单位： | 华中科技大学同济医学院心血管病研究所,武汉，430022 |
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| 摘 要： | 为研究培多普利对自发性高血压大鼠（SHR）左室心肌细胞凋亡和Bcl2,Bax基因表达的影响，采用TUNEL技术及DNA电泳研究心肌细胞凋亡，原位杂交研究Bcl2,Bax基因表达。结果显示，培多普勒（1）抑制左室心肌细胞凋亡发生。（2）使Bcl2/Bax基因表达比率恢复正常。提示：培多普利使SHR心肌Bcl2/Bax表达比率恢复正常是其抑制心室重塑过程中心肌细胞凋亡的重要机制。
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| 关 键 词： | 心室重构 培多普利 细胞凋亡 基因表达 Bcl2基因 Bax基因 心肌细胞 |
| 修稿时间： | 2001-03-12 |
The Effects of Peridopril on Apoptosis, Bcl2/Bax Gene Expression of Spontaneous Hypertension Rat Cardiac Myocyte during Ventricul ar Remodeling |
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| Huang Kai,Dai Guizhu Cardiovascular Disease Institute,Tongji Medical College,Huazhong University of Science and Technology,Wuhan. The Effects of Peridopril on Apoptosis, Bcl2/Bax Gene Expression of Spontaneous Hypertension Rat Cardiac Myocyte during Ventricul ar Remodeling[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2002, 31(1): 40-43 |
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| Authors: | Huang Kai Dai Guizhu Cardiovascular Disease Institute Tongji Medical College Huazhong University of Science Technology Wuhan |
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| Affiliation: | Huang Kai,Dai Guizhu Cardiovascular Disease Institute,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022 |
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| Abstract: | The effects of Peridopril on the cardiac myocyte apoptosis and Bcl 2 , Bax gene expression of spontaneous hypertension rat (SHR) were investigated. Tdt-mediated dUTP nick end labeling (TUNEL) method and DNA electrophoresis were used to study cardiac myocyte apoptosis. In situ hybridization was used to detect Bcl 2 , Bax gene expression in left ventricular cardiac myocyte. The results showed that Peridopril decreased the incidence of cardiac myocyte apoptosis of SHR; Peridopril restored the ratio of Bcl 2 /Bax gene expression. It was concluded that Peridopril restoring Bcl 2 /Bax gene expression ratio contributes to its effect of reducing cardiac myocyte apoptosis incidence during ventricular remodeling of SHR. |
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| Keywords: | ventricular remodeling Peridopril apoptosis Bcl 2 Bax gene expression |
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