Cortical region of interest definition on SPECT brain images using X-ray CT registration |
| |
Authors: | N. Tzourio M. Joliot B. M. Mazoyer V. Charlot D. Sutton G. Salamon |
| |
Affiliation: | (1) Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Orsay, France;(2) INSERM Unité U334, Orsay, France;(3) Service de Psychiatrie, Hôpital Louis Mourier, Colombes, France;(4) Antenne d'Informatique Médicale, C. H. U. Bichat, Paris, France;(5) Service de Neuroradiologie, CHU La Timone, Marseille, France |
| |
Abstract: | Summary We present a method for brain single photon emission computed tomography (SPECT) analysis based on individual registration of anatomical (CT) and functional (133Xe regional cerebral blood flow) images and on the definition of three-dimensional functional regions of interest. Registration of CT and SPECT is performed through adjustment of CT-defined cortex limits to the SPECT image. Regions are defined by sectioning a cortical ribbon on the CT images, copied over the SPECT images and pooled through slices to give 3D cortical regions of interest. The proposed method shows good intra- and interobserver reproducibility (regional intraclass correlation coefficient 0.98), and good accuracy in terms of repositioning (3.5 mm) as compared to the SPECT image resolution (14 mm). The method should be particularly useful for analysing SPECT studies when variations in brain anatomy (normal or abnormal) must be accounted for. |
| |
Keywords: | SPECT X-ray CT Image correlation rCPF |
本文献已被 SpringerLink 等数据库收录! |
|