| 水飞蓟宾-磷脂复合物的药代动力学和药效学研究进展 |
| |
| 引用本文： | 赵暖,栾立标. 水飞蓟宾-磷脂复合物的药代动力学和药效学研究进展[J]. 药学进展, 2006, 30(7): 295-299 |
| |
| 作者姓名： | 赵暖 栾立标 |
| |
| 作者单位： | 中国药科大学药剂学教研室,江苏,南京,210009 |
| |
| 摘 要： | 结合一系列体外实验、动物实验、人体实验及临床试验，综述水飞蓟宾-磷脂复合物的药代动力学、药效学及其安全性与耐受性的研究进展。大量的研究表明，与普通水飞蓟宾制剂相比，水飞蓟宾-磷脂复合物脂溶性增大，更容易透过细胞膜，吸收加快，生物利用度提高，活性增强，极具临床应用和研究价值。
|
| 关 键 词： | 水飞蓟宾 水飞蓟宾-磷脂复合物 脂溶性 生物利用度 药代动力学 药效学 |
| 文章编号： | 1001-5094（2006）07-0295-05 |
| 收稿时间： | 2006-05-15 |
| 修稿时间： | 2006-05-15 |
Recent Development in Pharmacokinetics and Pharmacodynamics of Silybin-phosphatidylcholine Complex |
| |
| ZHAO Nuan,LUAN Li-biao. Recent Development in Pharmacokinetics and Pharmacodynamics of Silybin-phosphatidylcholine Complex[J]. Progress in Pharmaceutical Sciences, 2006, 30(7): 295-299 |
| |
| Authors: | ZHAO Nuan LUAN Li-biao |
| |
| Affiliation: | Deparement of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China |
| |
| Abstract: | Recent development in the pharmacokinetics, pharmacodynamics, safety and tolerability of silybin-phosphatidylcholine complex was reviewed, by way of varied in vitro tests, animal and human experiments and clinical trials. Lots of related researches have shown that compared with common silybin preparations, silybin-phosphatidylcholine complex is more liposoluble, permeable through cell membrance and absorbable and has good bioavailability, resulting in increased activity, which has great value of clinical use and reseach. |
| |
| Keywords: | Silybin Silybin-phosphatidylcholine complex Liposoluble Bioavailability Phannacokinetics Pharmacodynamics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
