Clearance of indometacin occurs predominantly by renal glucuronidation |
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| Authors: | Frits Moolenaar Sjouke Crancrinus Jan Visser Dick De Zeeuw and Dirk K F Meijer |
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| Institution: | (1) Department of Pharmacology and Therapeutics, University Centre for Pharmacy, Ant. Deusinglaan 2, 9713 AW Groningen, the Netherlands;(2) Pharmacy Huis te Lande, Huis te Landelaan 476a, 2283 VJ Rijswijk, the Netherlands;(3) Department of Nephrology, University Hospital Groningen, P.O. Box 30.001, 9600 RB Groningen, the Netherlands |
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| Abstract: | In this report we describe the conditions of collection, storage and handling of urine samples, collected after oral dosing with indometacin in man, in order to maintain the integrity of the labile glucuronide formed. We found that the body clearance occurs predominantly by renal metabolism, due to glucuronidation in the human kidney. These glucuronides may be converted to isomeric glucuronides and/or the parent compound indometacin during the residence time in the bladder. |
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| Keywords: | Clearance metabolic Clearance renal Glucuronates Indometacin Pharmacokinetics |
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