夫西地酸治疗37例耐甲氧西林金黄色葡萄球菌性呼吸机相关性肺炎临床观察

目的 观察夫西地酸治疗耐甲氧西林金黄色葡萄球菌性呼吸机相关性肺炎临床疗效.方法 选择耐甲氧西林金黄色葡萄球菌性呼吸机相关性肺炎患者37例.应用夫西地酸钠0.5 g加入0.9%氯化钠注射液250 ml中,静脉滴注,1次/8 h,60 min滴入,连用10～14 d,观察其临床疗效、细菌清除率、肝肾功能变化、不良反应.结果夫西地酸治疗耐甲氧西林金黄色葡萄球菌性呼吸机相关性肺炎临床治愈率为67.6%,有效率为86.5%.细菌清除率为62.2%;治疗过程中对肝肾功能无明显影响;无明显不良反应.结论 夫西地酸作为一种安全性较高的药物,对耐甲氧西林金黄色葡萄球菌性呼吸机相关性肺炎效果较好.对于老年和(或)肾功能不良(或潜在不良)患者,可选择该药治疗.

Fusidic acid in treatment of 37 patients with ventilator-associated pneumonia caused by methicillin resistant Staphylococcus aureus

Objective To observc the clinical effect of fusidic acid in treating patients with ventilator-associated pneumonia caused by methicillin resistant Staphylococcus aureus(MRSA). Methods Thirty-seven patients with ventilator-associated pneumonia caused by MRSA were treated with fusidic acid for 10-14 days. Normal saline 250 ml with fusidic acid 0.5 g was intravenously administrated for 60 minutes,once per eight hours. The therapeutic effect in clinic, bacterium clearance rate, metergasis of liver and renal, amd adverse reaction were observed. Results The clinical cure rate was 67.6%, the effective rate was 86.5% ,and the clearance rate of bacteria was 62.2% after fusidic acid therapy. The incidence of adverse reaction was few,and it could not add liver and renal function injury. Conclusion Fusidic acid is effective and safe on patients with ventilator-associated pneumonia caused by MRSA,and can be used in the treatment of ventilator-associated pneumonia caused by MRSA. Elderly and(or) renal insufficiency (potentiality) patients can elect the therapy.