子宫内膜异位症与抗碳酸酐酶抗体的关系

目的 :探讨抗碳酸酐酶Ⅰ、Ⅱ抗体与子宫内膜异位症的关系。方法 :应用酶联免疫吸附 (ELISA)法分别检测内异症 32例、其他妇科疾病 (妇科组 ) 2 0例及正常妇女 12例血清抗碳酸酐酶抗体水平。结果 :(1)内异症患者血清抗碳酸酐酶Ⅰ、Ⅱ抗体阳性率(87.5 %、5 3.1% )高于妇科组 (2 5 %、15 % ) ,两组差异有显著性 (P <0 .0 1) ;(2 )内异症患者血清抗碳酸酐酶Ⅰ、Ⅱ抗体阳性率明显高于正常妇女组 (0 %、0 % ) ,两组差异有显著性 (P<0 .0 1) ;(3)妇科组及正常妇女组血清抗碳酸酐酶Ⅰ、Ⅱ抗体阳性率较低 ,两组差异无显著性 (P >0 .0 5 )。结论 :检测抗碳酸酐酶抗体对诊断子宫内膜异位症及探讨其发病机制有重要价值

The relation of endometriosis and anticarbonic anhydrase

Objective:To investigate the possibility of carbonic anhydrase (CA) level in diagnosing endometriosis.Methods:Antibody levels to human CA Ⅰ,Ⅱ in venous serum of32 patients with endometriosis,20 patients with other gynecologic disorders,and 12 normal women were measured by enzyme linked immunoassay (ELISA).Results: (1) The positive rates of CA Ⅰ and CA Ⅱ in patients with endometriosis were 87.5% and 53.1% respectively,which were significantly higher than those in patients with other gynecologic disorders (25% and 15%,P<0.01).(2)None of the normal women showed a positive reactivity to CAⅠ or CA Ⅱ.The positive rate of either CA Ⅰor CA Ⅱ in patients with endometriosis was significantly higher than that of normal women (P<0.01).(3)There was no significant difference (P>0.05) in CA Ⅰ and Ⅱ positive rates between normal women and patients with other gynecologic disorders. Conclusions:The level of autoantibody anainst CA may play an importmant role in the diagnosis and pathogenesis of endometrosis.