血管紧张素转化酶多态性与北京降压0号长期降压效果的关系

目的:探讨不同血管紧张素转化酶(ACE)基因插入/缺失(I/D)多态性的基因型的原发性高血压(EH)患者对北京降压0号治疗的长期反应性。方法:根据ACE I/D基因多态性,将EH患者分为II组(16例),ID组(11例)及DD组(15例),共42例。使用北京降压0号1片/d,共1年,观察降压疗效。结果:II组显效10例,有效5例,总有效率93.8%;ID组显效5例,有效4例,总有效率81.8%;DD组显效11例,有效2例,总有效率86.7%,控制率分别为75.0%、72.7%、60.0%,各组疗效差异无统计学意义(P>0.05),3组平均血压下降值比较,舒张压下降值II组高于ID组(P<0.05),其余均差异无统计学意义。结论:ACE I/D基因多态性对北京降压0号治疗EH的长期效果无影响。

Relationship between the efficacy of Beijing hypotensive No.0 and angiotensin converting enzyme gene I/D polymorphism

Objective:To study the correlation between angiotensin converting enzyme(ACE) genotypes and the long-term antihypertensive effects of Beijing hypotensive No 0 on essential hypertensive patients.Method:Forty-two patients were treated with Beijing hypotensive No 0,1 tablet per day for one year.The subjects were grouped into II,ID,and DD genotypes,and antihypertensive effects were compared among different ACE genotypes.Result:After one year treatment,the total effective rate in three groups were II 93.8%,ID 81.8%,DD 86.7%,and the control rate were 75.0%,72.7%,60.0%,There was no significant difference in the total effective rate and control rate among these three groups.the blood pressure decreasing in DBP was higher in II than ID(P<0.05).Conclusion:There was no difference between EH patients carrying different ACE genotypes responded to hypotensive No 0.