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| 树舌多糖GF对HepA瘤细胞C-myc基因表达的影响 | |
| 引用本文： | 宋高臣,曾惜秋,于水澜,于英君. 树舌多糖GF对HepA瘤细胞C-myc基因表达的影响[J]. 中医药学报, 2011, 39(4): 36-38 |
| 作者姓名： | 宋高臣 曾惜秋 于水澜 于英君 |
| 作者单位： | 1. 牡丹江医学院生物化学与分子生物学教研室,黑龙江省高校肿瘤疾病防治重点实验室,黑龙江牡丹江 157011 2. 牡丹江市传染病医院,黑龙江牡丹江,157011 3. 黑龙江中医药大学,黑龙江哈尔滨,150040 |
| 摘 要： | 目的:探明树舌多糖GF对HepA瘤组织C-myc基因表达的影响。方法:应用免疫组化和原位杂交方法检测小鼠HepA瘤细胞中C-myc基因的mRNA与蛋白的表达情况。结果:与荷瘤组比较,树舌多糖组、猪苓多糖组中C-myc基因的mRNA与蛋白的表达量均明显降低(P﹤0.01),其中树舌多糖组与猪苓多糖组无显著性差异。结论:树舌多糖GF可通过降低C-myc mRNA量及C-myc蛋白的表达,而抑制HepA瘤细胞的增殖。 |
| 关 键 词： | 树舌多糖GF HepA瘤细胞 C-myc基因 |
The Effect of Ganoderma Appanatum Polysaccharides GF on C - myc Oncogene Expression of HepA Tumour |
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| SONG Gao-chen,ZENG Xi-qiu,YU Shui-lan,YU Ying-jun. The Effect of Ganoderma Appanatum Polysaccharides GF on C - myc Oncogene Expression of HepA Tumour[J]. Acta Chinese Medicine and Pharmacology, 2011, 39(4): 36-38 | |
| Authors: | SONG Gao-chen ZENG Xi-qiu YU Shui-lan YU Ying-jun |
| Affiliation: | SONG Gao-chen1,ZENG Xi-qiu2,YU Shui-lan3,YU Ying-jun3(1.Mudanjiang Medical University,The Key Lab of Tumor Prevention and Treatment of Higher Education Institution in Heilongjiang,Mudanjiang 157011,China,2.Mudanjiang Infectious Hospital,3.Heilongjiang University of Chinese Medicine,Harbin 150040,China) |
| Abstract: | Objective:To study the effect of GAPSGF on C-myc mRNA and N-ras protein expression in HepA tumour.Methods :Immunohistochemical staining and ISH were used to determine the effect of Ganoderma appanatum polysaccharides GF on C-myc mRNA and C-myc protein expression in mouse HepA tumor.Results:The average levels of C-myc mRNA and C-myc protein expression in GAPSGF group and PUPS group have much difference with control group.That is to say,GAPSGF and PUPS can significantly reduce the expression of C-myc mRNA and... |
| Keywords: | Ganodermaw appanatum polysaccharides GF(GAPSGF) HepA tumor C-myc oncogene |
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