六甲蜜胺分子印迹聚合物的制备及其吸附性研究

目的以药物六甲蜜胺（Altretamine）为模板分子，合成不同功能单体的六甲蜜胺分子印迹聚合物（molecular imprinting polymer, MIP）并比较不同MIP之间的吸附性能。方法采用加热封管聚合法，将六甲蜜胺分别与功能单体甲基丙烯酸（MAA）、丙烯酰胺（AM）以及二者按一定比例的混合功能单体制备六甲蜜胺MIP，通过吸附性实验研究不同功能单体MIP吸附性能之间的差异，选出最适功能单体；并初步探索比较以相同功能单体不同方法（加热封管聚合法和悬浮聚合法）制备所得六甲蜜胺MIP的吸附性能。结果采用加热封管聚合法制备所得的甲基丙烯酸（MAA）．六甲蜜胺MIP对模板分子六甲蜜胺具有较好的选择吸附性，同时也初步显示采用悬浮聚合法，以同一功能单体制备所得的六甲蜜胺MIP的吸附性能要优于加热封管聚合法。结论六甲蜜胺MIP有望应用于临床对药物六甲蜜胺的痕量检测，优化临床药动学服务。

Preparation and Recognition of Altretamine Molecularly Imprinted Polymer

Objective The altretamine-molecularly imprinted polymer(MIP) was synthesized by methacrylic acid and acrylamide as functional monomer and to be compared with the selective recognition of MIPs.Methods Using methacrylic acid,acrylamide and both of them as functional monomer to synthesize altretamine MIPs,respectively,to select a suitable one evaluate by Scatchard equation;Furthermore,comparing with the selective recognition of MIPs which synthesized by the same functional monomer but in different methods(heat...