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| 补肾生血法对慢性再生障碍性贫血患者信号转导MAPK通路的影响 | |
| 引用本文： | 施海涛,王金环,孙岸弢,雍延礼,孙伟正.补肾生血法对慢性再生障碍性贫血患者信号转导MAPK通路的影响[J].中医药学报,2011,39(4):49-52. |
| 作者姓名： | 施海涛 王金环 孙岸弢 雍延礼 孙伟正 |
| 作者单位： | 1. 黑龙江省大庆龙南医院肾内科,黑龙江大庆,163000 2. 黑龙江中医药大学附属第一医院血液科,黑龙江哈尔滨,150040 3. 中国中医科学院临床基础研究所,北京,100000 |
| 基金项目： | 国家自然科学基金重大研究计划，高等学校博士学科点专项科研基金 |
| 摘 要： | 目的:观察补肾生血法对慢性再生障碍性贫血(CAA)的临床疗效,探索补髓生血颗粒对CAA患者骨髓基质细胞黏附信号转导MAPK通路的影响。方法:将CAA患者121例随机分为试验组60例、对照组61例进行临床试验研究,将患者治疗前后的骨髓基质细胞提取,分析黏附信号转导MAPK通路的相关酶类JNK、P38、ERK磷酸化的变化情况。结果:CAA患者骨髓基质细胞P-ERK1/2蛋白表达水平低于正常组(P<0.05),P-JNK与P-P38蛋白表达水平高于正常组(P<0.05);通过采用补肾生血法补髓生血颗粒治疗可以调整三种蛋白的异常表达,与治疗前比较(P均<0.05)。结论:CAA患者骨髓基质细胞造血粘附信号转导MAPK通路中酶类表达异常,这些可能是骨髓造血微环境粘附功能异常的原因之一,为CAA发病机制研究提供了分子生物学依据,本研究证明采用补肾生血法治疗CAA具有较好的疗效。 |
| 关 键 词： | 补肾生血法 慢性再生障碍性贫血 信号转导MAPK通路 |
The Effect of Bushen Shengxue Granules on Signal Transduction Pathway MAPK of Patients with Chronic Aplastic Anemia |
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| SHI Hai-tao,WANG Jin-huan,SUN An-tao,YONG Yan-Li,SUN Wei-zheng.The Effect of Bushen Shengxue Granules on Signal Transduction Pathway MAPK of Patients with Chronic Aplastic Anemia[J].Acta Chinese Medicine and Pharmacology,2011,39(4):49-52. | |
| Authors: | SHI Hai-tao WANG Jin-huan SUN An-tao YONG Yan-Li SUN Wei-zheng |
| Institution: | SHI Hai-tao1,WANG Jin-huan2,SUN An-tao3,YONG Yan-Li2,SUN Wei-zheng2(1.Daqing Longnan Hospital,Daqing 163000,China,2.The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,3.China Academy of Chinese Medical Sciences,Institute of Clinical Base,Beijing 100000,China) |
| Abstract: | Objective:To observe the clinical efficacy of Bushen Shengxue Granule(BSSXG) in chronic aplastic anemia(CAA) and discuss the differences in expression of signal transduction pathway MAPK before and after treatment.We observe the phosphorylation including ERK1/2,JNK,P38.Methods:124 cases of CAA were divided into two groups randomly.There are 61 cases who were used by BSSXG in experimental group,and 63 cases treatmented by Zaizaoshengxue Tablet in control group.The protein expression of enzymes P-ERK1/2,P-JNK... |
| Keywords: | Bushen Shengxue therapy Chronic Aplastic Anemia Signal transduction pathway MAPK |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |