| 风药对肝郁脾虚型UC大鼠结肠黏膜病理损伤的影响 |
| |
| 引用本文： | 马丽,郭军雄,王小莲.风药对肝郁脾虚型UC大鼠结肠黏膜病理损伤的影响[J].中医药学报,2011,39(5):43-45. |
| |
| 作者姓名： | 马丽 郭军雄 王小莲 |
| |
| 作者单位： | 张掖医学高等专科学校,甘肃张掖,734000 |
| |
| 基金项目： | 甘肃省教育厅基金资助项目(NO.1030-02) |
| |
| 摘 要： | 目的:本研究主要观察中药风药对肝郁脾虚型UC大鼠肠黏膜病理损伤的影响。方法:50只Wistar大鼠随机分为空白对照组、模型组、痛泻要方加风药组、痛泻要方组、痛泻要方祛防风组,每组10只,用结肠黏膜组织致敏法加乙酸局部刺激法建立大鼠复合溃疡性结肠炎模型后,用药组分别给予痛泻要方加风药、痛泻要方、痛泻要方祛防风药灌胃,模型对照组和正常对照组给予生理盐水,均灌胃4周后处死大鼠,分离其结肠组织,计算肠重指数,评价黏膜充血、组织损伤。结果:痛泻要方加风药、痛泻要方组在改善大鼠肠重指数、结肠黏膜充血、组织损伤方面明显优于痛泻要方祛防风组。结论:风药通过减轻UC模型大鼠结肠组织炎性反应,减缓黏膜充血水肿来促进实验性UC大鼠溃疡愈合的作用。
|
| 关 键 词： | 风药 溃疡性结肠炎 肠重指数 充血积分 组织损伤评分 |
The Effect of Fengyao on Experimental Ulcerative Colitis in Rats with Spleen Deifciency and Liver Depression |
| |
| MA Li,GUO Jun-xiong,WANG Xiao-lian.The Effect of Fengyao on Experimental Ulcerative Colitis in Rats with Spleen Deifciency and Liver Depression[J].Acta Chinese Medicine and Pharmacology,2011,39(5):43-45. |
| |
| Authors: | MA Li GUO Jun-xiong WANG Xiao-lian |
| |
| Institution: | MA Li,GUO Jun-xiong,WANG Xiao-lian(Zhangye Medical College,Zhangye 734000,China) |
| |
| Abstract: | Objective:To study the effect of Fengyao on experimental ulcerative colitis(UC) in rats with spleen deifciency and liver depression.Methods: Fifty healthy Wistar rats were randomly divided into 5 groups:normal control group,model group,TXYF+Fengyao,TXYF and TXYF-Fangfeng group(n=10 rats per group),The ulcerative colitis in the model group and positive group was developed by immunological sensitization with colon mucosal proteins and local irritation with five percent acetic acid.The rats of the model and po... |
| |
| Keywords: | Fengyao Ulcerative colitis Colonic weight index Colonic mucosal hyperemia Score of tissue damage |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
