| 活骨注射液髋关节腔注射对兔VEGF mRNA表达影响的研究 |
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| 引用本文： | 徐西林,张晓峰,段洪超,孙辉,高鹏. 活骨注射液髋关节腔注射对兔VEGF mRNA表达影响的研究[J]. 中医药信息, 2011, 28(5): 64-66 |
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| 作者姓名： | 徐西林 张晓峰 段洪超 孙辉 高鹏 |
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| 作者单位： | 1. 黑龙江中医大学附属第二医院,黑龙江哈尔滨,150001
2. 黑龙江中医大学,黑龙江哈尔滨,150040 |
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| 基金项目： | 黑龙江省中医药管理局课题,黑龙江中医药大学基金课题 |
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| 摘 要： | 目的：探讨活骨注射液髋关节腔注射治疗股骨头坏死（Osteonecrosis of the femoral head,ONFH）病程中股骨头局部血管内皮生长因子（vascular endothelial growth factor,VEGF）mRNA表达的变化及意义。方法：新西兰大白兔24只,随机分成对照组和治疗组,每组12只。液氮冷冻法复制股骨头坏死模型。治疗组给予活骨注射液髋关节腔注射,对照组给予生理盐水髋关节腔注射。两组动物分别于造模1、9周各处死6只,RT-PCT法行VEGFmRNA表达变化。结果：治疗组活骨注射液在ONFH治疗的过程中对VEGFmRNA的表达有影响（P〈0.01）,具有统计学意义;治疗时间因素对于ONFH治疗的过程中VEGF mRNA的表达有影响（P〈0.05）,具有统计学意义。结论：活骨注射液在ONFH治疗1周后可使VEGF mRNA的表达上调,其作用时间可以持续9周以上。
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| 关 键 词： | 活骨注射液 髋关节腔注射 股骨头坏死 血管内皮生长因子 |
The Effect of Huogu Injection for Hip Joint Cavity Injection on the Expression of VEGF mRNA of Rabbits |
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| XU Xi-lin,ZHANG Xiao-feng,DUAN Hong-chao,SUN Hui,GAO Peng. The Effect of Huogu Injection for Hip Joint Cavity Injection on the Expression of VEGF mRNA of Rabbits[J]. Information on Traditional Chinese Medicine, 2011, 28(5): 64-66 |
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| Authors: | XU Xi-lin ZHANG Xiao-feng DUAN Hong-chao SUN Hui GAO Peng |
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| Affiliation: | XU Xi-lin1,ZHANG Xiao-feng1,DUAN Hong-chao1,SUN Hui2,GAO Peng2(1.The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China,2.Heilongjiang University of Chinese Medicine,Harbin 150040,) |
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| Abstract: | Objective:To explore the change and the significance of vascular endothelial growth factor(VEGF) messenger RNA expressed in the osteonecrosis of the femoral head(ONFH).Method:24 new Zealand rabbits were randomly and equally divided into normal control group and model group.Each group contained 12 rabbits.The ONFH models were copied by liquid nitrogen refrigerating.The normal control group was injected Huogu injection into hip joint,and model group was injected normal saline into hip joint.The change of VEGF... |
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| Keywords: | Huogu injection Cavity injection of hip joint Femoral head necrosis Vascular endothelial growth factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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