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| 头针对脑缺血再灌注大鼠脑组织MMP-9表达调控的动态研究 | |
| 引用本文： | 孙晓伟,于学平,李洪涛,于春林,程化坤,滕伟,王冠.头针对脑缺血再灌注大鼠脑组织MMP-9表达调控的动态研究[J].中医药学报,2011,39(3):107-111. |
| 作者姓名： | 孙晓伟 于学平 李洪涛 于春林 程化坤 滕伟 王冠 |
| 作者单位： | 1. 黑龙江中医药大学附属第一医院,黑龙江哈尔滨,150040 2. 黑龙江省虎林市杨岗镇卫生院,黑龙江虎林,158404 3. 黑龙江省医院,黑龙江哈尔滨,150036 |
| 基金项目： | 教育部春晖计划项目，黑龙江省科技攻关项目，黑龙江省中医管理局项目，黑龙江中医药大学科研基金项目 |
| 摘 要： | 目的:探讨大鼠脑缺血再灌注后MMP-9的表达及早期头针干预对其的影响。方法:将205只SD大鼠随机分为假手术组、模型组和头针组。采用线栓法复制右侧大脑中动脉缺血再灌注模型;应用干湿比重法测定各组大鼠脑水含量;应用免疫组化和Western blot技术检测各组大鼠缺血侧脑组织MMP-9的表达。结果:头针组大鼠在再灌注24h、48h、72h,脑组织水含量较模型组显著降低(P<0.05)。再灌注各时间点头针组大鼠缺血侧脑组织MMP-9表达较模型组显著减少(P<0.05)。结论:早期进行头针治疗能够显著减少脑缺血再灌注后缺血侧脑组织中MMP-9的表达,减轻其脑水肿程度。MMP-9下调可能是该疗法拮抗脑缺血再灌注损伤的分子机制之一。 |
| 关 键 词： | 头针 脑梗死 缺血再灌注损伤 MMP-9 |
The Effect of Scalp Acupuncture on the Regulation of Brain Tissue MMP -9 Expression of Rats with Cerebral Ischemia Reperfusion Injury |
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| SUN Xiao-wei,YU Xue-ping,LI Hong-tao,YU Chun-lin,CHENG Hua-kun,TENG Wei,WANG Guan.The Effect of Scalp Acupuncture on the Regulation of Brain Tissue MMP -9 Expression of Rats with Cerebral Ischemia Reperfusion Injury[J].Acta Chinese Medicine and Pharmacology,2011,39(3):107-111. | |
| Authors: | SUN Xiao-wei YU Xue-ping LI Hong-tao YU Chun-lin CHENG Hua-kun TENG Wei WANG Guan |
| Institution: | SUN Xiao-wei1,YU Xue-ping1,LI Hong-tao1,YU Chun-lin2,CHENG Hua-kun3,TENG Wei1,WANG Guan1(1.The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China,2.Community Hospital of Yanggang County in Hulin,Hulin 158404,3.Heilongjiang Provincial Hospital,Harbin 150036,China) |
| Abstract: | Objective:To investigate the effects of scalp acupuncture on MMP-9 expression in the rats with cerebral ischemia reperfusion for exploring the interaction mechanisms.Methods:205 Male SD rats were divided randomly into three groups:sham group,model group,and scalp acupuncture group.Focal cerebral ischemia was induced by intraluminal middle cerebral artery occlusion and reperfusion(MCAO/R) method by using a monofilament thread in male SD rats.We observed the brain water content of each set with the method of ... |
| Keywords: | Scalp acupuncture Cerebral infarction Cerebral ischemia reperfusion injury Matrix Metalloproteinase-9 |
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